Background: Asthma is a heterogeneous disease with a wide range of clinical phenotypes,
not all of which may be encompassed in the subjects included in randomised controlled trials …

Rationale: Measurement of the fraction of nitric oxide in exhaled breath (Fe NO ) has been
proposed as a noninvasive marker of airway inflammation. Before the widespread use of this …

Background The Single combination budesonide–formoterol inhaler Maintenance And
Reliever Therapy (SMART) regimen reduces severe asthma exacerbations in patients, but …

BACKGROUND: COPD is a heterogeneous disease comprising a wide range of clinical
phenotypes, depending on the degree to which emphysema, chronic bronchitis, reversible …

A recent American Thoracic Society and European Respiratory Society joint Task Force report
recommends using a lower limit of normal (LLN) of forced expiratory volume in one second…

We studied the distribution profiles and repeatability of key exercise performance parameters
in the first large multicentre trials to include these measurements in chronic obstructive …

Exertional dyspnea is an important symptom in cancer patients, and, in many cases, its
cause remains unexplained after careful clinical assessment. To determine mechanisms of …

Background Electronic monitoring of inhaled asthma medications is one method to measure
medication adherence and patterns of use. Information on the performance of monitors in a …

Background Asthma and chronic obstructive pulmonary disease (COPD) are heterogeneous
disorders encompassing different phenotypes of airflow obstruction, which might differ in …

Serum periostin is a potential biomarker of response to therapies that target type 2 inflammation
in asthma. The objectives of this study were to describe: 1) the distribution of serum …