Protective immunity against influenza virus infection is mediated by neutralizing antibodies,
but the precise role of T cells in human influenza immunity is uncertain. We conducted …

Although the complexity and capability of flight simulators have matched the growth of
aerospace technology, there has until now been no textbook dealing specifically with the design …

Non-typeable Haemophilus influenzae (NTHi) is an ubiquitous commensal-turned-pathogen
that colonises the respiratory mucosa in airways diseases including Chronic Obstructive …

Under normal physiological conditions, the lung remains an oxygen rich environment.
However, prominent regions of hypoxia are a common feature of infected and inflamed tissues …

Background Alterations in the composition of the lung microbiome associated with adverse
clinical outcomes, known as dysbiosis, have been implicated with disease severity and …

Background Asthma is a chronic inflammatory disease involving diverse cells and mediators
whose interconnectivity and relationships to asthma severity are unclear. Objective We …

IL-10 is an important immunosuppressive cytokine that can down-regulate expression of
other cytokines and has been shown to down-regulate itself. We show, in this study, that …

Background The aetiology of acute exacerbations of COPD (AECOPD) is incompletely
understood. Understanding the relationship between chronic bacterial airway infection and viral …

BACKGROUND: Studies with monocyte-derived macrophages (MDMs) and animal models
have suggested a role for alternatively activated (M2) macrophages in asthmatic inflammation…

Background and Purpose Currently, there are no licensed vaccines and limited antivirals for
the treatment of COVID‐19. Heparin (delivered systemically) is currently used to treat …