An increase in intracellular calcium represents one of the early events during an ischaemic
stroke. It triggers many downstream processes which promote the formation of brain oedema, …

Cerebral ischaemia, associated with neuroinflammation and oxidative stress, is known to
perturb blood–brain barrier (BBB) integrity and promote brain oedema formation. Using an in …

Endothelial progenitor cells (EPCs), expressing markers for stemness (CD34), immaturity (CD133)
and endothelial maturity (KDR), may determine the extent of post-stroke vascular …

Breakdown of blood-brain barrier, formed mainly by brain microvascular endothelial cells (BMECs),
represents the major cause of mortality during early phases of ischemic strokes. …

Ischemic stroke is a devastating, life altering event which can severely reduce patient
quality of life. Despite years of research there have been minimal therapeutic advances. …

Ageing is characterised by a progressive loss of vascular endothelial function and integrity.
Endothelial progenitor cells (EPCs) play an integral role in endothelial regeneration but are …

Improved understanding of the key mechanisms underlying cerebral ischemic injury is essential
for the discovery of efficacious novel therapeutics for stroke. Through detailed analysis …

Ischaemic injury impairs the integrity of the blood–brain barrier (BBB). In this study, we
investigated the molecular causes of this defect with regard to the putative correlations among …

Asthma affects more than 300 million people globally and is both under diagnosed and
under treated. The most recent and largest genome-wide association study investigating …

Asthma is a multifactorial disease presenting with wheeze and shortness of breath, and is
known to be exacerbated by triggers such as pollen, house dust mites and viral infection. In …