The burden of treatment-resistant depression: a systematic review of the economic and quality of life literature

KM Johnston, LC Powell, IM Anderson, S Szabo… - Journal of affective …, 2019 - Elsevier
Background Major depressive disorder (MDD) is a global public health concern. In particular,
treatment-resistant depression (TRD) represents a key unmet need in the management of …

[HTML][HTML] The economic burden of prematurity in Canada

KM Johnston, K Gooch, E Korol, P Vo, O Eyawo… - BMC pediatrics, 2014 - Springer
Background Preterm birth is a major risk factor for morbidity and mortality among infants
worldwide, and imposes considerable burden on health, education and social services, as well …

[HTML][HTML] A review of published anticholinergic scales and measures and their applicability in database analyses

G Lozano-Ortega, KM Johnston, A Cheung… - Archives of gerontology …, 2020 - Elsevier
Background/objectives: Available metrics for characterizing cumulative anticholinergic
exposure over time may not be well suited for use across all US data sources. In this review, the …

[HTML][HTML] Methods of sample size calculation in descriptive retrospective burden of illness studies

KM Johnston, P Lakzadeh, BMK Donato… - BMC medical research …, 2019 - Springer
Background Observational burden of illness studies are used in pharmacoepidemiology to
address a variety of objectives, including contextualizing the current treatment setting, …

[HTML][HTML] The association between overactive bladder and falls and fractures: a systematic review

SM Szabo, KL Gooch, DR Walker, KM Johnston… - Advances in …, 2018 - Springer
Introduction Urinary symptoms are associated with an increased risk of falls, but few studies
have focused on patients with overactive bladder (OAB). This study aimed to synthesize …

Expanding access to HAART: a cost-effective approach for treating and preventing HIV

KM Johnston, AR Levy, VD Lima, RS Hogg… - Aids, 2010 - journals.lww.com
Objective: HIV continues to present a substantial global health burden. Given the high direct
medical costs associated with the disease, prevention of new transmission is an important …

[HTML][HTML] SABA use as an indicator for asthma exacerbation risk: an observational cohort study (SABINA Canada)

…, KM Johnston, M Soliman, M Talukdar… - ERJ Open …, 2022 - Eur Respiratory Soc
Background Patients with asthma use short-acting β-agonists (SABA) to relieve symptoms
but SABA alone does not treat underlying inflammation. Thus, over-reliance on SABA may …

The direct costs of HIV/AIDS care

AR Levy, D James, KM Johnston, RS Hogg… - The Lancet infectious …, 2006 - thelancet.com
We reviewed published studies reporting the direct medical costs of treating HIV-infected
people in countries using highly active antiretroviral therapy (HAART). Of 543 potentially …

[HTML][HTML] Mapping migraine-specific quality of life to health state utilities in patients receiving rimegepant

KM Johnston, G L'Italien, E Popoff, L Powell… - Advances in …, 2021 - Springer
Introduction Migraine is a debilitating neurological condition, affecting up to 15% of
Americans. Recent estimates from a long-term safety study of rimegepant showed evidence of …

International comparison of comparative effectiveness research in five jurisdictions: insights for the US

AR Levy, C Mitton, KM Johnston, B Harrigan… - …, 2010 - Springer
Spurred by a desire to improve quality of care and to understand the relative value of
medical treatments, there has been a recent surge of interest in publicly funded comparative …