User profiles for Karl J. Staples
Karl J StaplesProfessor of Respiratory Immunology & Pharmacology Verified email at port.ac.uk Cited by 4831 |
[HTML][HTML] Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans
Protective immunity against influenza virus infection is mediated by neutralizing antibodies,
but the precise role of T cells in human influenza immunity is uncertain. We conducted …
but the precise role of T cells in human influenza immunity is uncertain. We conducted …
Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations
Background Alterations in the composition of the lung microbiome associated with adverse
clinical outcomes, known as dysbiosis, have been implicated with disease severity and …
clinical outcomes, known as dysbiosis, have been implicated with disease severity and …
[HTML][HTML] Innate and adaptive T cells in asthmatic patients: relationship to severity and disease mechanisms
Background Asthma is a chronic inflammatory disease involving diverse cells and mediators
whose interconnectivity and relationships to asthma severity are unclear. Objective We …
whose interconnectivity and relationships to asthma severity are unclear. Objective We …
IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3
KJ Staples, T Smallie, LM Williams, A Foey… - The Journal of …, 2007 - journals.aai.org
IL-10 is an important immunosuppressive cytokine that can down-regulate expression of
other cytokines and has been shown to down-regulate itself. We show, in this study, that …
other cytokines and has been shown to down-regulate itself. We show, in this study, that …
A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD
Background The aetiology of acute exacerbations of COPD (AECOPD) is incompletely
understood. Understanding the relationship between chronic bacterial airway infection and viral …
understood. Understanding the relationship between chronic bacterial airway infection and viral …
Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17
KJ Staples, TSC Hinks, JA Ward, V Gunn… - Journal of allergy and …, 2012 - Elsevier
… Author links open overlay panel Karl J. Staples PhD a , Timothy SC Hinks MB BS a , Jon A.
Ward BSc (Hons) a , Victoria Gunn BM a , Caroline Smith BA (Hons) b , Ratko Djukanović MD …
Ward BSc (Hons) a , Victoria Gunn BM a , Caroline Smith BA (Hons) b , Ratko Djukanović MD …
Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations
Background and Purpose Currently, there are no licensed vaccines and limited antivirals for
the treatment of COVID‐19. Heparin (delivered systemically) is currently used to treat …
the treatment of COVID‐19. Heparin (delivered systemically) is currently used to treat …
Dysregulation of Antiviral Function of CD8+ T Cells in the Chronic Obstructive Pulmonary Disease Lung. Role of the PD-1–PD-L1 Axis
…, D Cellura, A Al-Shamkhani, KJ Staples… - American journal of …, 2016 - atsjournals.org
Rationale: Patients with chronic obstructive pulmonary disease (COPD) are susceptible to
respiratory viral infections that cause exacerbations. The mechanisms underlying this …
respiratory viral infections that cause exacerbations. The mechanisms underlying this …
Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD
…, S Bourne, NA Coombs, PT Elkington, KJ Staples… - Thorax, 2016 - thorax.bmj.com
Background Matrix metalloproteinases (MMPs) are proteolytic enzymes that can degrade
the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of …
the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of …
Multitissue transcriptomics delineates the diversity of airway T cell functions in asthma
…, CG Smith, D Horowitz, KJ Staples… - American journal of …, 2018 - atsjournals.org
Asthma arises from the complex interplay of inflammatory pathways in diverse cell types
and tissues. We sought to undertake a comprehensive transcriptomic assessment of the …
and tissues. We sought to undertake a comprehensive transcriptomic assessment of the …