User profiles for Karl J. Staples

Karl J Staples

Professor of Respiratory Immunology & Pharmacology
Verified email at port.ac.uk
Cited by 4831

[HTML][HTML] Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans

…, A Gilbert, J Oxford, B Nicholas, KJ Staples… - Nature medicine, 2012 - nature.com
Protective immunity against influenza virus infection is mediated by neutralizing antibodies,
but the precise role of T cells in human influenza immunity is uncertain. We conducted …

Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations

…, KK Ostridge, R Patel, G Sathe, DF Simola, KJ Staples… - Thorax, 2018 - thorax.bmj.com
Background Alterations in the composition of the lung microbiome associated with adverse
clinical outcomes, known as dysbiosis, have been implicated with disease severity and …

[HTML][HTML] Innate and adaptive T cells in asthmatic patients: relationship to severity and disease mechanisms

TSC Hinks, X Zhou, KJ Staples, BD Dimitrov… - Journal of allergy and …, 2015 - Elsevier
Background Asthma is a chronic inflammatory disease involving diverse cells and mediators
whose interconnectivity and relationships to asthma severity are unclear. Objective We …

IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3

KJ Staples, T Smallie, LM Williams, A Foey… - The Journal of …, 2007 - journals.aai.org
IL-10 is an important immunosuppressive cytokine that can down-regulate expression of
other cytokines and has been shown to down-regulate itself. We show, in this study, that …

A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD

…, AC Tuck, V Kim, K Ostridge, KJ Staples… - Thorax, 2017 - thorax.bmj.com
Background The aetiology of acute exacerbations of COPD (AECOPD) is incompletely
understood. Understanding the relationship between chronic bacterial airway infection and viral …

Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17

KJ Staples, TSC Hinks, JA Ward, V Gunn… - Journal of allergy and …, 2012 - Elsevier
… Author links open overlay panel Karl J. Staples PhD a , Timothy SC Hinks MB BS a , Jon A.
Ward BSc (Hons) a , Victoria Gunn BM a , Caroline Smith BA (Hons) b , Ratko Djukanović MD …

Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations

…, Z Yang, CM Spalluto, KJ Staples… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Currently, there are no licensed vaccines and limited antivirals for
the treatment of COVID‐19. Heparin (delivered systemically) is currently used to treat …

Dysregulation of Antiviral Function of CD8+ T Cells in the Chronic Obstructive Pulmonary Disease Lung. Role of the PD-1–PD-L1 Axis

…, D Cellura, A Al-Shamkhani, KJ Staples… - American journal of …, 2016 - atsjournals.org
Rationale: Patients with chronic obstructive pulmonary disease (COPD) are susceptible to
respiratory viral infections that cause exacerbations. The mechanisms underlying this …

Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD

…, S Bourne, NA Coombs, PT Elkington, KJ Staples… - Thorax, 2016 - thorax.bmj.com
Background Matrix metalloproteinases (MMPs) are proteolytic enzymes that can degrade
the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of …

Multitissue transcriptomics delineates the diversity of airway T cell functions in asthma

…, CG Smith, D Horowitz, KJ Staples… - American journal of …, 2018 - atsjournals.org
Asthma arises from the complex interplay of inflammatory pathways in diverse cell types
and tissues. We sought to undertake a comprehensive transcriptomic assessment of the …