DOCK family proteins: key players in immune surveillance mechanisms
K Kunimura, T Uruno, Y Fukui - International immunology, 2020 - academic.oup.com
Dedicator of cytokinesis (DOCK) proteins constitute a family of evolutionarily conserved
guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK …
guanine nucleotide exchange factors (GEFs) for the Rho family of GTPases. Although DOCK …
[HTML][HTML] Mass cytometry identifies characteristic immune cell subsets in bronchoalveolar lavage fluid from interstitial lung diseases
…, T Yanagihara, K Matsubara, K Kunimura… - Frontiers in …, 2023 - frontiersin.org
Immune cells have been implicated in interstitial lung diseases (ILDs), although their phenotypes
and effector mechanisms remain poorly understood. To better understand these cells, …
and effector mechanisms remain poorly understood. To better understand these cells, …
Cancer-derived cholesterol sulfate is a key mediator to prevent tumor infiltration by effector T cells
…, K Nishimoto, M Oyama, K Kunimura… - International …, 2022 - academic.oup.com
Effective tumor immunotherapy requires physical contact of T cells with cancer cells. However,
tumors often constitute a specialized microenvironment that excludes T cells from the …
tumors often constitute a specialized microenvironment that excludes T cells from the …
Selective role of neurokinin B in IL-31–induced itch response in mice
…, K Yamamura, Y Magoshi, K Kunimura… - Journal of Allergy and …, 2019 - jacionline.org
(DRG) neurons. 3 A recent clinical study has demonstrated that blockade of IL-31 signals by
a specific antibody for IL-31 receptor A alleviates pruritus in patients with AD. 4 However, the …
a specific antibody for IL-31 receptor A alleviates pruritus in patients with AD. 4 However, the …
The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development
K Kunimura, Y Fukui - International immunology, 2021 - academic.oup.com
Atopic dermatitis (AD) is one of the most prevalent chronic inflammatory skin diseases in the
world. It is characterized by recurrent eczematous lesions and intense itch, and many …
world. It is characterized by recurrent eczematous lesions and intense itch, and many …
[PDF][PDF] S100A4 protein is essential for the development of mature microfold cells in Peyer's patches
K Kunimura, D Sakata, X Tun, T Uruno, M Ushijima… - Cell Reports, 2019 - cell.com
Intestinal microfold cells (M cells) in Peyer's patches are a special subset of epithelial cells
that initiate mucosal immune responses through uptake of luminal antigens. Although the …
that initiate mucosal immune responses through uptake of luminal antigens. Although the …
[HTML][HTML] DOCK2 regulates MRGPRX2/B2-mediated mast cell degranulation and drug-induced anaphylaxis
K Kunimura, S Akiyoshi, T Uruno, K Matsubara… - Journal of Allergy and …, 2023 - Elsevier
Background Drug-induced anaphylaxis is triggered by the direct stimulation of mast cells (MCs)
via Mas-related G protein–coupled receptor X2 (MRGPRX2; mouse ortholog MRGPRB2)…
via Mas-related G protein–coupled receptor X2 (MRGPRX2; mouse ortholog MRGPRB2)…
[HTML][HTML] The Rac activator DOCK2 mediates plasma cell differentiation and IgG antibody production
…, F Sanematsu, Y Kamikaseda, K Kunimura… - Frontiers in …, 2018 - frontiersin.org
A hallmark of humoral immune responses is the production of antibodies. This process
involves a complex cascade of molecular and cellular interactions, including recognition of …
involves a complex cascade of molecular and cellular interactions, including recognition of …
[HTML][HTML] DOCK8 deficiency causes a skewing to type 2 immunity in the gut with expansion of group 2 innate lymphoid cells
K Matsubara, K Kunimura, N Yamane, R Aihara… - Biochemical and …, 2021 - Elsevier
Dedicator of cytokinesis 8 (DOCK8) is a guanine nucleotide exchange factor (GEF) for
Cdc42. In humans, homozygous or compound heterozygous deletions in DOCK8 cause a …
Cdc42. In humans, homozygous or compound heterozygous deletions in DOCK8 cause a …
[HTML][HTML] Pharmacological intervention of cholesterol sulfate-mediated T cell exclusion promotes antitumor immunity
…, Y Izumi, T Togo, Y Hattori, K Kunimura… - Biochemical and …, 2022 - Elsevier
Effective cancer immunotherapy requires physical contact of T cells with cancer cells.
However, tumors often constitute special microenvironments that exclude T cells and resist …
However, tumors often constitute special microenvironments that exclude T cells and resist …