P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study
R Abdulqawi, R Dockry, K Holt, G Layton, BG McCarthy… - The Lancet, 2015 - thelancet.com
Background Preclinical studies suggest that P2X3 receptors are expressed by airway vagal
afferent nerves and contribute to the hypersensitisation of sensory neurons. P2X3 receptors …
afferent nerves and contribute to the hypersensitisation of sensory neurons. P2X3 receptors …
Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: a double-blind randomized controlled trial
…, A Newlands, K Smart, A Kelsall, K Holt… - Journal of allergy and …, 2014 - Elsevier
Background Inhalation of capsaicin, the extract of hot chili peppers, induces coughing in both
animals and human subjects through activation of transient receptor potential vanilloid 1 (…
animals and human subjects through activation of transient receptor potential vanilloid 1 (…
[HTML][HTML] Objective cough frequency in idiopathic pulmonary fibrosis
AL Key, K Holt, A Hamilton, JA Smith, JE Earis - Cough, 2010 - Springer
Background Cough is a common presenting symptom in patients with Idiopathic Pulmonary
Fibrosis (IPF). This study measured cough rates in IPF patients and investigated the …
Fibrosis (IPF). This study measured cough rates in IPF patients and investigated the …
XEN-D0501, a novel transient receptor potential vanilloid 1 antagonist, does not reduce cough in patients with refractory cough
Rationale: Heightened cough responses to inhaled capsaicin, a transient receptor potential
vanilloid 1 (TRPV1) agonist, are characteristic of patients with chronic cough. However, …
vanilloid 1 (TRPV1) agonist, are characteristic of patients with chronic cough. However, …
Neurophenotypes in airway diseases. Insights from translational cough studies
…, MA Wortley, R Dockry, J Coote, K Holt… - American journal of …, 2016 - atsjournals.org
Rationale: Most airway diseases, including chronic obstructive pulmonary disease (COPD),
are associated with excessive coughing. The extent to which this may be a consequence of …
are associated with excessive coughing. The extent to which this may be a consequence of …
Gefapixant in two randomised dose-escalation studies in chronic cough
…, P Butera, SA Smith, Y Li, ZJ Xu, K Holt… - European …, 2020 - Eur Respiratory Soc
Background and objectives Gefapixant has previously demonstrated efficacy in the treatment
of refractory chronic cough at a high daily dose. The current investigations explore efficacy …
of refractory chronic cough at a high daily dose. The current investigations explore efficacy …
[HTML][HTML] Capsaicin-evoked cough responses in asthmatic patients: evidence for airway neuronal dysfunction
I Satia, N Tsamandouras, K Holt, H Badri… - Journal of Allergy and …, 2017 - Elsevier
Background Cough in asthmatic patients is a common and troublesome symptom. It is
generally assumed coughing occurs as a consequence of bronchial hyperresponsiveness and …
generally assumed coughing occurs as a consequence of bronchial hyperresponsiveness and …
Aprepitant for cough in lung cancer. A randomized placebo-controlled trial and mechanistic insights
JA Smith, A Harle, R Dockry, K Holt… - American Journal of …, 2021 - atsjournals.org
Rationale: Effective cough treatments are a significant unmet need in patients with lung
cancer. Aprepitant is a licensed treatment for nausea and vomiting, which blocks substance P …
cancer. Aprepitant is a licensed treatment for nausea and vomiting, which blocks substance P …
Performance of a digital signal processing algorithm for the accurate quantification of cough frequency
JA Smith, K Holt, R Dockry, S Sen… - European …, 2021 - Eur Respiratory Soc
The ability to measure cough frequency from sound recordings has changed the standards
by which new cough treatments are evaluated and is providing insights into the mechanisms …
by which new cough treatments are evaluated and is providing insights into the mechanisms …
Cough in patients with lung cancer: a longitudinal observational study of characterization and clinical associations
…, A Molassiotis, J Yorke, R Dockry, KJ Holt… - Chest, 2019 - Elsevier
Background Cough is common in patients with lung cancer, and current antitussive treatments
are suboptimal. There are little published data describing cough in patients with lung …
are suboptimal. There are little published data describing cough in patients with lung …