P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study

R Abdulqawi, R Dockry, K Holt, G Layton, BG McCarthy… - The Lancet, 2015 - thelancet.com
Background Preclinical studies suggest that P2X3 receptors are expressed by airway vagal
afferent nerves and contribute to the hypersensitisation of sensory neurons. P2X3 receptors …

Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: a double-blind randomized controlled trial

…, A Newlands, K Smart, A Kelsall, K Holt… - Journal of allergy and …, 2014 - Elsevier
Background Inhalation of capsaicin, the extract of hot chili peppers, induces coughing in both
animals and human subjects through activation of transient receptor potential vanilloid 1 (…

[HTML][HTML] Objective cough frequency in idiopathic pulmonary fibrosis

AL Key, K Holt, A Hamilton, JA Smith, JE Earis - Cough, 2010 - Springer
Background Cough is a common presenting symptom in patients with Idiopathic Pulmonary
Fibrosis (IPF). This study measured cough rates in IPF patients and investigated the …

XEN-D0501, a novel transient receptor potential vanilloid 1 antagonist, does not reduce cough in patients with refractory cough

…, SA Maher, I Satia, H Badri, K Holt… - American journal of …, 2017 - atsjournals.org
Rationale: Heightened cough responses to inhaled capsaicin, a transient receptor potential
vanilloid 1 (TRPV1) agonist, are characteristic of patients with chronic cough. However, …

Neurophenotypes in airway diseases. Insights from translational cough studies

…, MA Wortley, R Dockry, J Coote, K Holt… - American journal of …, 2016 - atsjournals.org
Rationale: Most airway diseases, including chronic obstructive pulmonary disease (COPD),
are associated with excessive coughing. The extent to which this may be a consequence of …

Gefapixant in two randomised dose-escalation studies in chronic cough

…, P Butera, SA Smith, Y Li, ZJ Xu, K Holt… - European …, 2020 - Eur Respiratory Soc
Background and objectives Gefapixant has previously demonstrated efficacy in the treatment
of refractory chronic cough at a high daily dose. The current investigations explore efficacy …

[HTML][HTML] Capsaicin-evoked cough responses in asthmatic patients: evidence for airway neuronal dysfunction

I Satia, N Tsamandouras, K Holt, H Badri… - Journal of Allergy and …, 2017 - Elsevier
Background Cough in asthmatic patients is a common and troublesome symptom. It is
generally assumed coughing occurs as a consequence of bronchial hyperresponsiveness and …

Aprepitant for cough in lung cancer. A randomized placebo-controlled trial and mechanistic insights

JA Smith, A Harle, R Dockry, K Holt… - American Journal of …, 2021 - atsjournals.org
Rationale: Effective cough treatments are a significant unmet need in patients with lung
cancer. Aprepitant is a licensed treatment for nausea and vomiting, which blocks substance P …

Performance of a digital signal processing algorithm for the accurate quantification of cough frequency

JA Smith, K Holt, R Dockry, S Sen… - European …, 2021 - Eur Respiratory Soc
The ability to measure cough frequency from sound recordings has changed the standards
by which new cough treatments are evaluated and is providing insights into the mechanisms …

Cough in patients with lung cancer: a longitudinal observational study of characterization and clinical associations

…, A Molassiotis, J Yorke, R Dockry, KJ Holt… - Chest, 2019 - Elsevier
Background Cough is common in patients with lung cancer, and current antitussive treatments
are suboptimal. There are little published data describing cough in patients with lung …