[HTML][HTML] Update on genetics of primary aldosteronism

K Itcho, K Oki, H Ohno, M Yoneda - Biomedicines, 2021 - mdpi.com
Primary aldosteronism (PA) is the most common form of secondary hypertension, with a
prevalence of 5–10% among patients with hypertension. PA is mainly classified into two …

Calneuron 1 Increased Ca2+ in the Endoplasmic Reticulum and Aldosterone Production in Aldosterone-Producing Adenoma

…, EP Gomez-Sanchez, H Ohno, K Itcho… - …, 2018 - Am Heart Assoc
Aldosterone production is initiated by angiotensin II stimulation and activation of intracellular
Ca 2+ signaling. In aldosterone-producing adenoma (APA) cells, the activation of …

Endoplasmic reticulum chaperone calmegin is upregulated in aldosterone-producing adenoma and associates with aldosterone production

K Itcho, K Oki, CE Gomez-Sanchez… - …, 2020 - Am Heart Assoc
The endoplasmic reticulum (ER) plays a pivotal role in syntheses of proteins and steroid
hormones and regulation of intracellular Ca 2+ level. We aimed to investigate ER-associated …

Genetic risk of primary aldosteronism and Its contribution to hypertension: a cross-ancestry meta-analysis of genome-wide association studies

…, R Baba, T Kodama, Y Otagaki, A Okada, K Itcho… - Circulation, 2023 - Am Heart Assoc
Background: Hypertension imposes substantial health and economic burden worldwide.
Primary aldosteronism (PA) is one of the most common causes of secondary hypertension, …

Aberrant G protein-receptor expression is associated with DNA methylation in aldosterone-producing adenoma

K Itcho, K Oki, K Kobuke, Y Yoshii, H Ohno… - Molecular and Cellular …, 2018 - Elsevier
This study aimed to evaluate the methylation levels of G protein-coupled receptor (GPCR)
related genes and the effects of methylation on mRNA expression levels in aldosterone-…

Hypomethylation of CYP11B2 in aldosterone-producing adenoma

…, K Oki, CE Gomez-Sanchez, H Ohno, K Itcho… - …, 2016 - Am Heart Assoc
The purpose of this study was to evaluate the DNA methylation levels of steroidogenic
enzyme genes in aldosterone-producing adenoma (APA) and the effects of gene mutations in …

Angiotensin 1-7 suppresses angiotensin II mediated aldosterone production via JAK/STAT signaling inhibition

K Itcho, K Oki, K Kobuke, H Ohno, M Yoneda… - The Journal of Steroid …, 2019 - Elsevier
Angiotensin 1-7 (Ang 1-7), which is a protein cleaved from angiotensin II (A-II), binds to the
MAS receptor. Ang 1-7 has been demonstrated to exert protective effects against A-II-…

Genotype-specific cortisol production associated with Cushing's syndrome adenoma with PRKACA mutations

…, K Oki, CE Gomez-Sanchez, Y Otagaki, K Itcho… - Molecular and cellular …, 2021 - Elsevier
The intracellular molecular mechanisms underlying the genotype of cortisol-producing adenoma
(CPA) have not been fully determined. We analyzed gene expressions in CPA and the …

[HTML][HTML] Gonadotropin-releasing hormone stimulate aldosterone production in a subset of aldosterone-producing adenoma

…, CE Gomez-Sanchez, H Ohno, K Kobuke, K Itcho… - Medicine, 2016 - journals.lww.com
We aimed to detect novel genes associated with G protein-coupled receptors (GPCRs) in
aldosterone-producing adenoma (APA) and elucidate the mechanisms underlying …

Association between serum elaidic acid concentration and insulin resistance in two Japanese cohorts with different lifestyles

K Itcho, Y Yoshii, H Ohno, K Oki… - … of Atherosclerosis and …, 2017 - jstage.jst.go.jp
Aim: Many cohort studies have shown that increased trans fatty acid (TFA) intake increases
the risk of developing coronary heart disease. However, whether TFA intake is directly …