User profiles for Kristin Siggeirsdottir

Kristin Siggeirsdottir

Icelandic Heart Association/Janus Rehabilitation
Verified email at janus.is
Cited by 6414

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

…, J Prezelj, LM Rose, S Scollen, K Siggeirsdottir… - Nature …, 2012 - nature.com
Bone mineral density (BMD) is the most widely used predictor of fracture risk. We performed
the largest meta-analysis to date on lumbar spine and femoral neck BMD, including 17 …

[HTML][HTML] Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention

…, LJ Scott, RA Scott, S Sidney, K Siggeirsdottir… - Nature …, 2022 - nature.com
Although physical activity and sedentary behavior are moderately heritable, little is known
about the mechanisms that influence these traits. Combining data for up to 703,901 …

Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture

…, AOGC Consortium, AV Smith, K Siggeirsdottir… - Nature, 2015 - nature.com
The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare (MAF
≤ 1%) variants contribute to complex traits and disease in the general population is …

Imminent risk of fracture after fracture

H Johansson, K Siggeirsdóttir, NC Harvey… - Osteoporosis …, 2017 - Springer
The risk of major osteoporotic fracture (MOF) after a first MOF is increased over the whole
duration of follow-up, but the imminent risk is even higher. If the acute increment in risk in the …

Assessment of incident spine and hip fractures in women and men using finite element analysis of CT scans

…, S Sigurdsson, K Siggeirsdottir… - Journal of Bone and …, 2014 - academic.oup.com
Finite element analysis of computed tomography (CT) scans provides noninvasive estimates
of bone strength at the spine and hip. To further validate such estimates clinically, we …

Vertebral bone marrow fat associated with lower trabecular BMD and prevalent vertebral fracture in older adults

…, CJ Rosen, E Vittinghoff, K Siggeirsdottir… - The Journal of …, 2013 - academic.oup.com
Context: Bone marrow fat (BMF) and bone mineral density (BMD) by dual x-ray energy
absorptiometry (DXA) are negatively correlated. However, little is known about the association of …

Physical activity and incidence of sarcopenia: the population-based AGES—Reykjavik Study

…, V Gudnason, G Eiriksdottir, K Siggeirsdottir… - Age and …, 2016 - academic.oup.com
Background: the prevalence of sarcopenia increases with age. Physical activity might slow
the rate of muscle loss and therewith the incidence of sarcopenia. Objective: to examine the …

Comparison of handgrip and leg extension strength in predicting slow gait speed in older adults

…, A Koster, A Newman, K Siggeirsdottir… - Journal of the …, 2016 - Wiley Online Library
Objectives To compare the relative predictive power of handgrip and leg extension strength
in predicting slow walking. Design Report of correlative analysis from two epidemiological …

Characteristics of recurrent fractures

…, KM Sanders, G Sigurdsson, K Siggeirsdottir… - Osteoporosis …, 2018 - Springer
The present study, drawn from a sample of the Icelandic population, quantified high immediate
risk and utility loss of subsequent fracture after a sentinel fracture (at the hip, spine, distal …

Muscle quality and myosteatosis: novel associations with mortality risk: the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study

…, M Visser, L Launer, K Siggeirsdottir… - American journal of …, 2016 - academic.oup.com
Muscle composition may affect mortality risk, but prior studies have been limited to specific
samples or less precise determination of muscle composition. We evaluated associations of …