New methods and technologies within the field of lung biology are beginning to shed new
light into the microbial world of the respiratory tract. Long considered to be a sterile …

Microaspiration is a common phenomenon in healthy subjects, but its frequency is
increased in chronic inflammatory airway diseases, and its role in inflammatory and immune …

Background The lung microbiome of healthy individuals frequently harbors oral organisms.
Despite evidence that microaspiration is commonly associated with smoking-related lung …

Multiple lines of investigation have shown that the gut microbiota affects host immune
response to immunotherapy in cancer. Here, we support that the local airway microbiota …

Despite mounting evidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
engagement with immune cells, most express little, if any, of the canonical receptor of …

Rationale: In lung cancer, upregulation of the PI3K (phosphoinositide 3-kinase) pathway is
an early event that contributes to cell proliferation, survival, and tissue invasion. Upregulation …

Chronic obstructive pulmonary disease (COPD) is a prevalent, heterogeneous disorder with
varying presentation and progression but with a limited number of disease-modifying …

Respiratory failure is associated with increased mortality in COVID-19 patients. There are
no validated lower airway biomarkers to predict clinical outcome. We investigated whether …

Background Airway abnormalities and lung tissue citrullination are found in both rheumatoid
arthritis (RA) patients and individuals at-risk for disease development. This suggests the …

Introduction Azithromycin (AZM) reduces pulmonary inflammation and exacerbations in
patients with COPD having emphysema. The antimicrobial effects of AZM on the lower airway …