User profiles for Laura K. Fawcett
 | Laura K FawcettSydney Children's Hospital Verified email at health.nsw.gov.au Cited by 180 |
[HTML][HTML] Human primary epithelial cell models: promising tools in the era of cystic fibrosis personalized medicine
…, SL Wong, CK Hewson, LK Fawcett… - Frontiers in …, 2018 - frontiersin.org
Cystic fibrosis (CF) is an inherited disorder where individual disease etiology and response
to therapeutic intervention is impacted by CF transmembrane regulator (CFTR) mutations …
to therapeutic intervention is impacted by CF transmembrane regulator (CFTR) mutations …
[HTML][HTML] Significant functional differences in differentiated Conditionally Reprogrammed (CRC)-and Feeder-free Dual SMAD inhibited-expanded human nasal …
…, I Slapetova, L Zhong, N Turgutoglu, LK Fawcett… - Journal of Cystic …, 2021 - Elsevier
Background Patient-derived airway cells differentiated at Air Liquid Interface (ALI) are valuable
models for Cystic fibrosis (CF) precision therapy. Different culture expansion methods …
models for Cystic fibrosis (CF) precision therapy. Different culture expansion methods …
Molecular dynamics and theratyping in airway and gut organoids reveal R352Q-CFTR conductance defect
A significant challenge to making targeted cystic fibrosis transmembrane conductance
regulator (CFTR) modulator therapies accessible to all individuals with cystic fibrosis (CF) are …
regulator (CFTR) modulator therapies accessible to all individuals with cystic fibrosis (CF) are …
[HTML][HTML] Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a …
Background: Cystic fibrosis (CF) is caused by a wide spectrum of mutations in the CF
transmembrane conductance regulator (CFTR) gene, with some leading to non-classical clinical …
transmembrane conductance regulator (CFTR) gene, with some leading to non-classical clinical …
[HTML][HTML] Comparing Cytology Brushes for Optimal Human Nasal Epithelial Cell Collection: Implications for Airway Disease Diagnosis and Research
LK Fawcett, N Turgutoglu, KM Allan, Y Belessis… - Journal of Personalized …, 2023 - mdpi.com
Primary nasal epithelial cells and culture models are used as important diagnostic, research
and drug development tools for several airway diseases. Various instruments have been …
and drug development tools for several airway diseases. Various instruments have been …
Collection, expansion, and differentiation of primary human nasal epithelial cell models for quantification of cilia beat frequency
Measurements of cilia function (beat frequency, pattern) have been established as diagnostic
tools for respiratory diseases such as primary ciliary dyskinesia. However, the wider …
tools for respiratory diseases such as primary ciliary dyskinesia. However, the wider …
[HTML][HTML] S945L-CFTR molecular dynamics, functional characterization and tezacaftor/ivacaftor efficacy in vivo and in vitro in matched pediatric patient-derived cell …
Cystic Fibrosis (CF) results from over 400 different disease-causing mutations in the CF
Transmembrane Conductance Regulator (CFTR) gene. These CFTR mutations lead to …
Transmembrane Conductance Regulator (CFTR) gene. These CFTR mutations lead to …
[PDF][PDF] Molecular dynamics and functional characterization of I37R-CFTR lasso mutation provide insights into channel gating activity
Characterization of I37R, a mutation located in the lasso motif of the CFTR chloride channel,
was conducted by theratyping several CFTR modulators from both potentiator and corrector …
was conducted by theratyping several CFTR modulators from both potentiator and corrector …
[HTML][HTML] Avatar acceptability: views from the Australian Cystic Fibrosis community on the use of personalised organoid technology to guide treatment decisions
LK Fawcett, CE Wakefield, S Sivam… - ERJ open …, 2021 - Eur Respiratory Soc
Background Patient-oriented research approaches that reflect the needs and priorities of those
most affected by health research outcomes improves translation of research findings into …
most affected by health research outcomes improves translation of research findings into …
Providing Australian children and adolescents with equitable access to new and emerging therapies through clinical trials: a call to action
MS Lorentzos, D Metz, AS Moore, LK Fawcett… - The Medical Journal of …, 2024 - mja.com.au
Opportunities for children to benefit from novel therapies have increased substantially over
the past decade. Change is needed to maximise these opportunities, particularly in the …
the past decade. Change is needed to maximise these opportunities, particularly in the …