MAPK phosphatases—regulating the immune response

Y Liu, EG Shepherd, LD Nelin - Nature Reviews Immunology, 2007 - nature.com
Mitogen-activated protein kinase (MAPK) phosphatases (MKPs) are protein phosphatases
that dephosphorylate both the phosphothreonine and phosphotyrosine residues on activated …

MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock

Q Zhao, X Wang, LD Nelin, Y Yao, R Matta… - The Journal of …, 2006 - rupress.org
Septic shock is a leading cause of morbidity and mortality. However, genetic factors
predisposing to septic shock are not fully understood. Excessive production of proinflammatory …

Interdisciplinary care of children with severe bronchopulmonary dysplasia

…, PK Donohue, E Austin, C Fike, LD Nelin - The Journal of …, 2017 - jpeds.com
Advances in perinatal care have dramatically im-proved survival of extremely preterm infants
and the incidence of bronchopulmonary dysplasia (BPD) has not changed over the past …

Role of endothelin in intermittent hypoxia-induced hypertension

NL Kanagy, BR Walker, LD Nelin - Hypertension, 2001 - Am Heart Assoc
Clinical studies suggest that sleep apnea causes systemic hypertension. In addition, patients
with sleep apnea have elevated plasma levels of endothelin-1 (ET-1). We hypothesized …

[HTML][HTML] The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory …

Q Zhao, EG Shepherd, ME Manson, LD Nelin… - Journal of Biological …, 2005 - ASBMB
Mitogen-activated protein (MAP) kinases are critical mediators of innate immune responses.
In response to lipopolysaccharide (LPS), MAP kinases are rapidly activated and play an …

Arginase inhibition increases nitric oxide production in bovine pulmonary arterial endothelial cells

…, ML Paffett, TL Young, LD Nelin - American Journal of …, 2004 - journals.physiology.org
Nitric oxide (NO) is produced by NO synthase (NOS) from l-arginine (l-Arg). Alternatively, l-Arg
can be metabolized by arginase to produce l-ornithine and urea. Arginase (AR) exists in …

Initial laparotomy versus peritoneal drainage in extremely low birthweight infants with surgical necrotizing enterocolitis or isolated intestinal perforation: a multicenter …

…, GE Besner, A Das, RK Ohls, WE Truog, LD Nelin… - 2021 - journals.lww.com
Objective: The aim of this study was to determine which initial surgical treatment results in
the lowest rate of death or neurodevelopmental impairment (NDI) in premature infants with …

A simple distensible vessel model for interpreting pulmonary vascular pressure-flow curves

JH Linehan, ST Haworth, LD Nelin… - Journal of Applied …, 1992 - journals.physiology.org
A simple distensible vessel model was developed for the purpose of interpreting the vascular
pressure-flow curve in the zone 3 lung. The model-governing equation has two parameters…

Admission temperature and associated mortality and morbidity among moderately and extremely preterm infants

…, DD Appel, LC Miller, PJ Sanchez, LD Nelin… - The Journal of …, 2018 - Elsevier
Objective To evaluate the temperature distribution among moderately preterm (MPT, 29-33
weeks) and extremely preterm (EPT, <29 weeks) infants upon neonatal intensive care unit (…

The impact of pulmonary hypertension in preterm infants with severe bronchopulmonary dysplasia through 1 year

…, S Vyas-Read, S Yallapragada, LD Nelin… - The Journal of …, 2018 - Elsevier
Objectives To assess the effect of pulmonary hypertension on neonatal intensive care unit
mortality and hospital readmission through 1 year of corrected age in a large multicenter …