There is a link between high lipopolysaccharide (LPS) levels in the blood and the metabolic
syndrome, and metabolic syndrome predisposes patients to severe COVID-19. Here, we …

Background Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that
strongly activates dendritic cells and can initiate allergic inflammation. Since exposure to …

Background Mast cell-derived prostaglandin D 2 (PGD 2 ), may contribute to eosinophilic
inflammation and mucus production in allergic asthma. Chemoattractant receptor homologous …

Pathogenic granulocytes (eosinophils and neutrophils) infiltrate airway tissues in asthma
and chronic obstructive pulmonary disease. Granulocytes release tissue-toxic and …

Background Thymic stromal lymphopoietin (TSLP), an epithelial upstream cytokine, initiates
production of type 2 cytokines with eosinophilia and possibly airway hyperresponsiveness (…

Rhinovirus infection is a major cause of chronic obstructive pulmonary disease (COPD)
exacerbations and may contribute to the development into severe stages of COPD. The …

Background Viral-induced asthma exacerbations, which exhibit both Th1-type neutrophilia
and Th2-type inflammation, associate with secretion of Interleukin (IL)-1β. IL-1β induces …

Background: Rhinovirus (RV)-induced chronic obstructive pulmonary disease (COPD)
exacerbations exhibit TH 2 -like inflammation. We hypothesized that RV-infected bronchial …

Asthma is a heterogeneous disease in which various environmental stimuli as well as
different genes, cell types, cytokines and mediators are implicated. This chronic inflammatory …

Rationale: Allergic asthma is linked to impaired bronchial epithelial secretion of IFNs, which
may be causally linked to the increased risk of viral exacerbations. We have previously …