Genomic insights into the formation of human populations in East Asia

…, OA Shubina, J Guo, W Cai, Q Deng, L Kang… - Nature, 2021 - nature.com
The deep population history of East Asia remains poorly understood owing to a lack of
ancient DNA data and sparse sampling of present-day people 1 , 2 . Here we report genome-wide …

[PDF][PDF] Ancestral origins and genetic history of Tibetan highlanders

…, Y Yang, S Li, L Jin, Y Guan, B Su, L Kang… - The American Journal of …, 2016 - cell.com
The origin of Tibetans remains one of the most contentious puzzles in history, anthropology,
and genetics. Analyses of deeply sequenced (30×–60×) genomes of 38 Tibetan highlanders …

A mitochondrial revelation of early human migrations to the Tibetan Plateau before and after the last glacial maximum

Z Qin, Y Yang, L Kang, S Yan, K Cho… - American Journal of …, 2010 - Wiley Online Library
As the highest plateau surrounded by towering mountain ranges, the Tibetan Plateau was
once considered to be one of the last populated areas of modern humans. However, this view …

mtDNA lineage expansions in Sherpa population suggest adaptive evolution in Tibetan highlands

L Kang, HX Zheng, F Chen, S Yan, K Liu… - Molecular biology …, 2013 - academic.oup.com
Sherpa population is an ethnic group living in south mountainside of Himalayas for hundreds
of years. They are famous as extraordinary mountaineers and guides, considered as a …

[HTML][HTML] Differentiated demographic histories and local adaptations between Sherpas and Tibetans

…, L Liu, Y Yang, S Li, L Ma, Z Zhang, L Jin, B Su, L Kang… - Genome Biology, 2017 - Springer
Background The genetic relationships reported by recent studies between Sherpas and
Tibetans are controversial. To gain insights into the population history and the genetic basis of …

[PDF][PDF] A 3.4-kb copy-number deletion near EPAS1 is significantly enriched in high-altitude Tibetans but absent from the Denisovan sequence

…, X Wang, Q Feng, S Wu, Y Yang, S Li, L Kang… - The American Journal of …, 2015 - cell.com
Tibetan high-altitude adaptation (HAA) has been studied extensively, and many candidate
genes have been reported. Subsequent efforts targeting HAA functional variants, however, …

Genome-wide association study identifies a new locus at 7q21. 13 associated with hepatitis B virus–related hepatocellular carcinoma

…, T Liu, H Zhang, J An, JX Bei, W Jia, L Kang… - Clinical Cancer …, 2018 - AACR
Purpose: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. In
China, chronic hepatitis B virus (HBV) infection remains the major risk factor for HCC. In this …

The genomic formation of human populations in East Asia

…, K Shinoda, OA Shubina, J Guo, Q Deng, L Kang… - BioRxiv, 2020 - biorxiv.org
The deep population history of East Asia remains poorly understood due to a lack of ancient
DNA data and sparse sampling of present-day people. We report genome-wide data from …

[HTML][HTML] Effects of altitude on human oral microbes

…, L Liu, J Li, W Dong, H Zhang, S Bai, L Ma, L Kang - AMB Express, 2021 - Springer
Human oral microbes play a vital role maintaining host metabolic homeostasis. The Qinghai-Tibet
Plateau is mainly characterized by a high altitude, dry, cold, and hypoxic environment. …

Bone mesenchymal stem cells transplanted into rabbit intervertebral discs can increase proteoglycans

YG Zhang, X Guo, P Xu, LL Kang… - Clinical Orthopaedics and …, 2005 - journals.lww.com
We sought to determine whether transplanted allogeneic bone mesenchymal stem cells can
survive and increase the amount of proteoglycans in intervertebral discs. We used the rabbit …