User profiles for Lorenzo Bonaguro
Lorenzo BonaguroUniversity of Bonn, DZNE Bonn & UKB Bonn Verified email at uni-bonn.de Cited by 3516 |
[HTML][HTML] A guide to systems-level immunomics
The immune system is highly complex and distributed throughout an organism, with hundreds
to thousands of cell states existing in parallel with diverse molecular pathways interacting …
to thousands of cell states existing in parallel with diverse molecular pathways interacting …
[PDF][PDF] Severe COVID-19 is marked by a dysregulated myeloid cell compartment
…, B Krämer, T Krammer, S Brumhard, L Bonaguro… - Cell, 2020 - cell.com
Coronavirus disease 2019 (COVID-19) is a mild to moderate respiratory tract infection, however,
a subset of patients progress to severe disease and respiratory failure. The mechanism …
a subset of patients progress to severe disease and respiratory failure. The mechanism …
[HTML][HTML] Human monocyte subsets and phenotypes in major chronic inflammatory diseases
Human monocytes are divided in three major populations; classical (CD14 + CD16 − ), non-classical
(CD14 dim CD16 + ), and intermediate (CD14 + CD16 + ). Each of these subsets is …
(CD14 dim CD16 + ), and intermediate (CD14 + CD16 + ). Each of these subsets is …
[HTML][HTML] Neutrophils in COVID-19
N Reusch, E De Domenico, L Bonaguro… - Frontiers in …, 2021 - frontiersin.org
Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …
neutrophils play an important role in the pathophysiology, particularly in those with severe …
[PDF][PDF] Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19
Longitudinal analyses of the innate immune system, including the earliest time points, are
essential to understand the immunopathogenesis and clinical course of coronavirus disease (…
essential to understand the immunopathogenesis and clinical course of coronavirus disease (…
[HTML][HTML] Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation
…, S Warnat-Herresthal, L Bonaguro… - Frontiers in …, 2022 - frontiersin.org
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive
pulmonary disease (COPD) are far from being understood. Here, we determine disease-…
pulmonary disease (COPD) are far from being understood. Here, we determine disease-…
[HTML][HTML] Swarm learning for decentralized and confidential clinical machine learning
Fast and reliable detection of patients with severe and heterogeneous illnesses is a major
goal of precision medicine 1 , 2 . Patients with leukaemia can be identified using machine …
goal of precision medicine 1 , 2 . Patients with leukaemia can be identified using machine …
[HTML][HTML] Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients
…, M Nuesch-Germano, K Gkizeli, L Bonaguro… - Genome medicine, 2021 - Springer
Background The SARS-CoV-2 pandemic is currently leading to increasing numbers of
COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild …
COVID-19 patients all over the world. Clinical presentations range from asymptomatic, mild …
[PDF][PDF] Complement activation induces excessive T cell cytotoxicity in severe COVID-19
P Georg, R Astaburuaga-García, L Bonaguro… - Cell, 2022 - cell.com
Severe COVID-19 is linked to both dysfunctional immune response and unrestrained
immunopathology, and it remains unclear whether T cells contribute to disease pathology. Here, …
immunopathology, and it remains unclear whether T cells contribute to disease pathology. Here, …
[PDF][PDF] Systemic alterations in neutrophils and their precursors in early-stage chronic obstructive pulmonary disease
Systemic inflammation is established as part of late-stage severe lung disease, but molecular,
functional, and phenotypic changes in peripheral immune cells in early disease stages …
functional, and phenotypic changes in peripheral immune cells in early disease stages …