The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts
U-BIOPRED aims to characterise paediatric and adult severe asthma using conventional
and innovative systems biology approaches. A total of 99 school-age children with severe …
and innovative systems biology approaches. A total of 99 school-age children with severe …
Sputum inflammatory phenotypes are not stable in children with asthma
Background Two distinct, stable inflammatory phenotypes have been described in adults
with asthma: eosinophilic and non-eosinophilic. Treatment strategies based on these …
with asthma: eosinophilic and non-eosinophilic. Treatment strategies based on these …
The importance of nurse-led home visits in the assessment of children with problematic asthma
M Bracken, L Fleming, P Hall, N Van Stiphout… - Archives of disease in …, 2009 - adc.bmj.com
Objective: To evaluate and identify potentially modifiable factors in children with problematic
asthma by a nurse-led assessment and home visit. Design: Observational cohort study. …
asthma by a nurse-led assessment and home visit. Design: Observational cohort study. …
Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes
…, JM Drazen, JM FitzGerald, LJ Fleming… - American journal of …, 2022 - atsjournals.org
The Global Initiative for Asthma (GINA) Strategy Report provides clinicians with an annually
updated evidence-based strategy for asthma management and prevention, which can be …
updated evidence-based strategy for asthma management and prevention, which can be …
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
…, AR Sousa, SJ Fowler, LJ Fleming… - European …, 2015 - Eur Respiratory Soc
U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical
companies and six patient organisations with the objective of improving the understanding …
companies and six patient organisations with the objective of improving the understanding …
[HTML][HTML] Key recommendations for primary care from the 2022 Global Initiative for Asthma (GINA) update
The Global Initiative for Asthma (GINA) was established in 1993 by the World Health
Organization and the US National Heart Lung and Blood Institute to improve asthma awareness, …
Organization and the US National Heart Lung and Blood Institute to improve asthma awareness, …
GINA 2019: a fundamental change in asthma management: treatment of asthma with short-acting bronchodilators alone is no longer recommended for adults and …
…, R Buhl, AA Cruz, L Fleming… - European …, 2019 - Eur Respiratory Soc
GINA no longer recommends treating adults/adolescents with asthma with short-acting
bronchodilators alone. Instead, they should receive symptom-driven (in mild asthma) or a daily …
bronchodilators alone. Instead, they should receive symptom-driven (in mild asthma) or a daily …
Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI)
Patients with severe refractory asthma pose a major healthcare problem. Over the last decade
it has become increasingly clear that, for the development of new targeted therapies, there …
it has become increasingly clear that, for the development of new targeted therapies, there …
Pediatric severe asthma is characterized by eosinophilia and remodeling without TH2 cytokines
BACKGROUND: The pathology of pediatric severe therapy-resistant asthma (STRA) is little
understood. OBJECTIVES: We hypothesized that STRA in children is characterized by …
understood. OBJECTIVES: We hypothesized that STRA in children is characterized by …
U-BIOPRED clinical adult asthma clusters linked to a subset of sputum omics
Background Asthma is a heterogeneous disease in which there is a differential response to
asthma treatments. This heterogeneity needs to be evaluated so that a personalized …
asthma treatments. This heterogeneity needs to be evaluated so that a personalized …