Obesity increases the risk of cardiovascular disease and premature death. Adipose tissue
releases a large number of bioactive mediators that influence not only body weight …

Leptin is a mainly adipocyte-secreted protein that was discovered 5 years ago. Most of the
research following this discovery focused on the role of leptin in body weight regulation, …

Several large epidemiological studies have shown an association between body mass
index and blood pressure in normal weight and overweight patients. Weight gain in adult life …

Background Obesity is a global health challenge with few pharmacologic options. Whether
adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of 2.4 …

Background In animal models, cannabinoid-1 receptor (CB 1 ) blockade produces a lean
phenotype, with resistance to diet-induced obesity and associated dyslipidaemia. We …

Background The long-term effects of sibutramine treatment on the rates of cardiovascular
events and cardiovascular death among subjects at high cardiovascular risk have not been …

Background Sibutramine is a tertiary amine that has been shown to induce dose-dependent
weight loss and to enhance the effects of a low-calorie diet for up to a year. We did a …

… Van Gaal was involved in the analysis and interpretation of the study. Drs. Heine and Van
Gaal had full access to the trial data and had primary control of the decision to submit the …

Background The frequency of obesity has risen dramatically in recent years but only few
safe and effective drugs are currently available. We assessed the effect of liraglutide on …

Background Glucagon-like peptide 1 receptor agonists differ in chemical structure, duration
of action, and in their effects on clinical outcomes. The cardiovascular effects of once-weekly …