Recent studies have revealed biologically significant differences between human and
mouse lung development, and have reported new in vitro systems that allow experimental …

Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …

It is not fully understood why COVID-19 is typically milder in children 1 , 2 – 3 . Here, to examine
the differences between children and adults in their response to SARS-CoV-2 infection, …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re)define tissue architecture of …

Purpose of Review The lung research field has pioneered the use of organoids for the study
of cell-cell interactions. Recent Findings The use of organoids for airway basal cells is …

Mesothelioma is an aggressive cancer that is associated with exposure to asbestos. Although
asbestos is banned in several countries, including the UK, an epidemic of mesothelioma is …

There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…

Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …

10.7554/eLife.26575.001 The embryonic mouse lung is a widely used substitute for human
lung development. For example, attempts to differentiate human pluripotent stem cells to lung …

Heterozygous germ-line mutations in the bone morphogenetic protein type-II receptor (BMPR-II)
gene underlie heritable pulmonary arterial hypertension (HPAH). Although inflammation …