Background Oral immunotherapy is an emerging experimental treatment for peanut allergy,
but its benefits and harms are unclear. We systematically reviewed the efficacy and safety of …

IL-6 is induced often together with the proinflammatory cytokines TNFalpha and IL-1 in
many alarm conditions, and circulating IL-6 plays an important role in the induction of acute …

The outcome of T-cell responses after T-cell encounter with specific antigens is modulated by
co-stimulatory signals, which are required for both lymphocyte activation and development …

The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current
COVID-19 vaccines administered intramuscularly and designed to only target the spike …

We investigated the in vivo function of the B7 family member B7-H3 (also known as B7RP-2)
by gene targeting. B7-H3 inhibited T cell proliferation mediated by antibody to T cell …

The increase in thickness of bronchial walls by such structural changes as subepithelial
fibrosis contributes to the severity and chronicity of asthma by amplifying airway narrowing. …

Chronically inflamed and fibrotic tissue of the respiratory tract can be shown to actively express
the genes and products of a number of powerful growth and differentiating factors. The …

It is now fully appreciated that asthma is a disease of a chronic nature resulting from
intermittent or continued aeroallergen exposure leading to airway inflammation. To investigate …

BACKGROUND: Allergen exposure at lung and gut mucosae can lead to aberrant T H 2
immunity and allergic disease. The epithelium-associated cytokines thymic stromal …

It is now well established that passive exposure to inhaled OVA leads to a state of immunological
tolerance. Therefore, to elicit allergic sensitization, researchers have been compelled …