Rationale: Acute pulmonary oxygen sensing is essential to avoid life-threatening hypoxemia
via hypoxic pulmonary vasoconstriction (HPV) which matches perfusion to ventilation. …

Increased mitochondrial reactive oxygen species (ROS), particularly superoxide, have been
suggested to mediate hypoxic pulmonary vasoconstriction (HPV), chronic hypoxia-induced …

Acute respiratory distress syndrome (ARDS) is a serious complication of severe systemic or
local pulmonary inflammation, such as caused by severe acute respiratory syndrome …

Background and Purpose Chronic obstructive pulmonary disease, encompassing chronic
airway obstruction and lung emphysema, is a major worldwide health problem and a severe …

Background The brain-derived neurotrophic factor (BDNF) may promote development of
pulmonary hypertension and right ventricular (RV) failure. However, BDNF plasma levels were …

Aims The pulmonary vascular tone and hypoxia-induced alterations of the pulmonary
vasculature may be regulated by the mitochondrial membrane permeability transition pore (mPTP) …

Acute and sustained hypoxic pulmonary vasoconstriction (HPV), as well as chronic pulmonary
hypertension (PH), is modulated by nitric oxide (NO). NO synthesis can be decreased by …

In addition to its renowned poisonous effects, carbon monoxide (CO) is being recognized
for its beneficial actions on inflammatory and vasoregulatory pathways, particularly when …

The mitochondrial adaptor protein p66Shc has been suggested to control life span in mice
via the release of hydrogen peroxide. However, the role of p66Shc in lung aging remains …

The mitochondrial protein p66shc enhances production of mitochondrial reactive oxygen
species (ROS) in response to cellular stress, probably via the mitochondrial protein cyclophilin …