Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis

…, N Figg, JJ Maguire, AP Davenport, M Goddard… - Nature medicine, 2006 - nature.com
Vascular smooth muscle cell (VSMC) apoptosis occurs in many arterial diseases, including
aneurysm formation, angioplasty restenosis and atherosclerosis. Although VSMC apoptosis …

Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis: effects of telomerase and oxidative stress

…, N Figg, P Kirkpatrick, A Ritchie, M Goddard… - Circulation …, 2006 - Am Heart Assoc
Although human atherosclerosis is associated with aging, direct evidence of cellular
senescence and the mechanism of senescence in vascular smooth muscle cells (VSMCs) in …

Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration

…, N Figg, JJ Maguire, AP Davenport, M Goddard… - Circulation …, 2008 - Am Heart Assoc
Vascular smooth muscle cell (VSMC) accumulation is implicated in plaque development. In
contrast, VSMC apoptosis is implicated in plaque rupture, coagulation, vessel remodeling, …

The landscape of somatic mutation in normal colorectal epithelial cells

…, N Georgakopoulos, F Torrente, A Noorani, M Goddard… - Nature, 2019 - nature.com
The colorectal adenoma–carcinoma sequence has provided a paradigmatic framework for
understanding the successive somatic genetic changes and consequent clonal expansions …

The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of …

…, M Fedrigo, MC Fishbein, M Goddard… - The Journal of Heart and …, 2013 - Elsevier
During the last 25 years, antibody-mediated rejection of the cardiac allograft has evolved
from a relatively obscure concept to a recognized clinical complication in the management of …

Identifying inflamed carotid plaques using in vivo USPIO-enhanced MR imaging to label plaque macrophages

…, MJ Graves, J Horsley, MJ Goddard… - … , and vascular biology, 2006 - Am Heart Assoc
Background— Inflammation within atherosclerotic lesions contributes to plaque instability
and vulnerability to rupture. We set out to evaluate the use of a macrophage labeling agent to …

Monocyte/macrophage suppression in CD11b diphtheria toxin receptor transgenic mice differentially affects atherogenesis and established plaques

…, N Figg, J Mercer, R Lang, M Goddard… - Circulation …, 2007 - Am Heart Assoc
Although monocytes/macrophages are considered important in atherogenesis, their role in
established plaques is unclear. For example, macrophage content is associated with plaque …

Distinct epigenomic features in end-stage failing human hearts

…, L Siggens, A Vujic, I Simeoni, C Penkett, M Goddard… - Circulation, 2011 - Am Heart Assoc
Background— The epigenome refers to marks on the genome, including DNA methylation
and histone modifications, that regulate the expression of underlying genes. A consistent …

[HTML][HTML] ACE2 gene expression is up-regulated in the human failing heart

AB Goulter, MJ Goddard, JC Allen, KL Clark - BMC medicine, 2004 - Springer
Background ACE2 is a novel homologue of angiotensin converting enzyme (ACE). ACE2 is
highly expressed in human heart and animal data suggest that ACE2 is an essential …

In vivo detection of macrophages in human carotid atheroma: temporal dependence of ultrasmall superparamagnetic particles of iron oxide-enhanced MRI

…, MJ Graves, JJ Cross, J Horsley, MJ Goddard… - Stroke, 2004 - Am Heart Assoc
Background— It has been suggested that inflammatory cells within vulnerable plaques may
be visualized by superparamagnetic iron oxide particle-enhanced MRI. The purpose of this …