User profiles for Matthew A. Cooper

Matthew A. Cooper

The University of Cambridge
Verified email at cam.ac.uk
Cited by 35566

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

…, P Chines, R Clarke, LJM Coin, MN Cooper… - Nature …, 2010 - nature.com
Levels of circulating glucose are tightly regulated. To identify new loci influencing glycemic
traits, we performed meta-analyses of 21 genome-wide association studies informative for …

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

…, F Wiklund, C Barlassina, DI Chasman, MN Cooper… - Nature …, 2010 - nature.com
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain
largely elusive. To identify genetic loci for obesity susceptibility, we examined associations …

Hundreds of variants clustered in genomic loci and biological pathways affect human height

…, G Boucher, DI Chasman, C Chen, L Coin, MN Cooper… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

…, KHG Mills, SL Masters, K Schroder, MA Cooper… - Nature medicine, 2015 - nature.com
The NOD-like receptor (NLR) family, pyrin domain–containing protein 3 (NLRP3) inflammasome
is a component of the inflammatory process, and its aberrant activation is pathogenic in …

Optical biosensors in drug discovery

MA Cooper - Nature reviews Drug discovery, 2002 - nature.com
Optical biosensors that exploit surface plasmon resonance, waveguides and resonant mirrors
have been used widely over the past decade to analyse biomolecular interactions. These …

[HTML][HTML] Emerging pathogenic links between microbiota and the gut–lung axis

…, SL Gellatly, DLA Wood, MA Cooper… - Nature Reviews …, 2017 - nature.com
The microbiota is vital for the development of the immune system and homeostasis. Changes
in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut …

Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice

…, S Jacob, V Muralidhar, AAB Robertson, MA Cooper… - Science, 2017 - science.org
Human aging is associated with an increased frequency of somatic mutations in hematopoietic
cells. Several of these recurrent mutations, including those in the gene encoding the …

Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution

…, RM Watanabe, R Welch, DI Chasman, MN Cooper… - Nature …, 2010 - nature.com
Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic
consequences independent of overall adiposity. WHR is heritable, but few genetic variants …

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

…, GN Ioannou, SL Masters, K Schroder, MA Cooper… - Journal of …, 2017 - Elsevier
Background & Aims NOD-like receptor protein 3 (NLRP3) inflammasome activation occurs in
Non-alcoholic fatty liver disease (NAFLD). We used the first small molecule NLRP3 inhibitor…

[HTML][HTML] Fix the antibiotics pipeline

MA Cooper, D Shlaes - Nature, 2011 - nature.com
… As resistance mushrooms, governments must make development of new antibiotics
financially viable for industry, say Matthew A. Cooper and David Shlaes. … Matthew A. …