Sepsis is the leading cause of death in the intensive care unit and ranks in the top 10
causes of death in general worldwide. Proinflammatory mediators are related to symptoms …

Excessive or persistent proinflammatory cytokine production plays a central role in autoimmune
diseases. Acute activation of the sympathetic nervous system attenuates the innate …

The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Methods| All patients in this study were admitted to the intensive care unit (ICU) of Radboud
University Medical Center. Plasma concentrations of the proinflammatory cytokines tumor …

Sepsis involves simultaneous hyperactivation of the immune system and immune paralysis,
leading to both organ dysfunction and increased susceptibility to secondary infections. Acute …

Fast and reliable detection of patients with severe and heterogeneous illnesses is a major
goal of precision medicine 1 , 2 . Patients with leukaemia can be identified using machine …

Background Anakinra might improve the prognosis of patients with moderate to severe
COVID-19 (ie, patients requiring oxygen supplementation but not yet receiving organ support). …

Innate immune memory is the phenomenon whereby innate immune cells such as
monocytes or macrophages undergo functional reprogramming after exposure to microbial …

The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages
in some patients, immunoparalysis may be encountered, which is associated with a poor …

Increasing evidence supports a central role of the immune system in sepsis, but the current
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European Group …