CONTEXT: Randomized controlled trials can answer questions of efficacy, but long-term
pharmacovigilance studies generate complementary safety data. OBJECTIVES: Level I …

Breathlessness that persists despite treatment for the underlying conditions is debilitating.
Identifying this discrete entity as a clinical syndrome should raise awareness amongst patients…

Malnutrition predicts poorer clinical outcomes for people with cancer. Older adults with cancer
are a complex, growing population at high risk of weight-losing conditions. A number of …

Globally, the number of people affected by coronavirus disease 2019 (COVID-19) is rapidly
increasing. In most (>80%), the illness is relatively mild and can be self-managed out of …

Contrary to common perception, modern palliative care (PC) is applicable to all people with
an incurable disease, not only cancer. PC is appropriate at every stage of disease …

Background Many people are dying from coronavirus disease 2019 (COVID-19), but consensus
guidance on palliative care in COVID-19 is lacking. This new life-threatening disease …

Context Clinically important differences in chronic refractory breathlessness are ill defined but
important in clinical practice and trial design. Objectives To estimate the clinical relevance …

What is the experience of people living with breathlessness due to medical conditions,
those caring for them and those treating them, with regard to quality of life and the nature of …

Results Of 494 articles screened, 12 studies (conducted from 1985 to 2014) were included.
These involved 206 patients (most receiving hemodialysis) and 64 health care professionals (…

The efficacy of low-dose systemic opioids for chronic breathlessness was questioned by the
recent Cochrane review by Barnes et al. We examined the reasons for this conflicting finding …