This article reviews the evidence that pretreatment with nicotine causes a regionally selective
sensitization of its stimulatory effects on a pathway, the mesoaccumbens dopamine (DA) …

Importance Malignant pleural effusion (MPE) is challenging to manage. Talc pleurodesis is
a common and effective treatment. There are no reliable data, however, regarding the …

Bronchoalveolar lavage (BAL) is a key clinical and research tool in lung transplantation (LTx).
However, BAL collection and processing are not standardized across LTx centers. This …

Rationale: Patients with malignant pleural effusion experience breathlessness, which is
treated by drainage and pleurodesis. Incomplete drainage results in residual dyspnea and …

Background The demand for lung transplantation vastly exceeds the availability of donor
organs. This translates into long waiting times and high waiting list mortality. We set out to …

Background Lung transplantation (LTx) is widely accepted as a therapeutic option for end-stage
respiratory failure in cystic fibrosis. However, airway complications remain a major …

Cytomegalovirus (CMV) disease caused by genetically resistant CMV poses a major challenge
in solid organ transplant recipients, and the development of resistance is associated with …

Although acute renal failure has been described in children with CF in relation to intravenous
aminoglycoside use, there are no reports in the adult CF literature. We describe 8 cases of …

Cytomegalovirus (CMV) is the most important infectious agent in solid organ transplant
recipients and has a major impact on morbidity and mortality. Most cases are well managed with …

Background: Repeated courses of intravenous (IV) aminoglycosides in cystic fibrosis (CF)
patients are associated with cumulative nephrotoxicity. Targeting their delivery through the …