The study of autophagy (‘self‐eating’), a fundamental cell fate pathway involved in physiological
and pathological subcellular processes, opens a new frontier in the continuous search …

The presence of eosinophilic inflammation is a characteristic feature of chronic and acute
inflammation in asthma. An estimated 5%–10% of the 300 million people worldwide who suffer …

Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and
structural airway abnormalities that impact disease persistence and severity. Recent progress …

Background: Subepithelial collagen and extracellular matrix protein deposition are important
pathophysiological components of airway remodelling in chronic asthma. Animal models …

Background: The fractional exhaled nitric oxide (FE NO ) test is a point-of-care test that is used
in the assessment of asthma. Objective: To provide evidence-based clinical guidance on …

Idiopathic pulmonary fibrosis (IPF) is a lethal fibrotic lung disease in adults with limited treatment
options. Autophagy and the unfolded protein response (UPR), fundamental processes …

The mevalonate (MEV) cascade is responsible for cholesterol biosynthesis and the
formation of the intermediate metabolites geranylgeranylpyrophosphate (GGPP) and …

The Th1/Th2 paradigm has become an important issue in the pathogenesis of asthma,
characterized by normal Th1 and elevated Th2 cytokine expression. Vitamin A deficiency (VAD) …

Rationale: Statin use has been linked to improved lung health in asthma and chronic obstructive
pulmonary disease. We hypothesize that statins inhibit allergic airway inflammation and …

Autophagy, apoptosis, and the unfolded protein response (UPR) are fundamental biological
processes essential for manifold cellular functions in health and disease. Idiopathic …