Objectives: To determine whether baseline plasma levels of the receptor for advanced
glycation end products (RAGE), a novel marker of alveolar type I cell injury, are associated with …

Urine neutrophil gelatinase-associated lipocalin (uNGAL) has shown promise as a biomarker
for the early detection of acute kidney injury (AKI) in fixed models of injury, but its ability to …

Introduction Despite recent modifications, the clinical definition of the acute respiratory
distress syndrome (ARDS) remains non-specific, leading to under-diagnosis and under-treatment. …

Background: The diagnosis of acute lung injury (ALI) is based on a consensus clinical definition.
Despite the simplicity of this definition, ALI remains underdiagnosed and undertreated. …

Background Two acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory
and hypoinflammatory) with distinct clinical and biological features and differential …

Background Acute lung injury (ALI) is a major cause of acute respiratory failure with high
mortality despite lung-protective ventilation. Prior work has shown disordered inflammation and …

Background and objectives: Urine IL-18 (uIL-18) has demonstrated moderate capacity to
predict acute kidney injury (AKI) and adverse outcomes in defined settings. Its ability to predict …

Rationale: Obesity has been linked to acute lung injury and is a risk factor for early mortality
after lung transplantation. Objectives: To examine the associations of obesity and plasma …

Objective: To determine the association of circulating cell-free hemoglobin with poor clinical
outcomes in patients with sepsis and to characterize the potential protective effects of …

Women have higher prevalence of asthma compared with men. In asthma, allergic airway
inflammation is initiated by IL-33 signaling through ST2, leading to increased IL-4, IL-5, and IL-…