Rhinoviruses are the major cause of asthma exacerbations, and asthmatics have increased
susceptibility to rhinovirus and risk of invasive bacterial infections. Here we show deficient …

Rationale: Rhinoviruses are the major cause of asthma exacerbations; however, its
underlying mechanisms are poorly understood. We hypothesized that the epithelial cell–derived …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease of unknown
cause that leads to respiratory failure and death within 5 years of diagnosis. Overt respiratory …

Asthma is the most common chronic respiratory disease, affecting up to 10% of adults and
30% of children in the Western world. Despite advances in asthma management, acute …

Rationale: Rhinovirus infection is followed by significantly increased frequencies of positive,
potentially pathogenic sputum cultures in chronic obstructive pulmonary disease (COPD). …

Rationale: Respiratory virus infections are associated with chronic obstructive pulmonary
disease (COPD) exacerbations, but a causative relationship has not been proven. Studies of …

Acute exacerbations are the major cause of asthma morbidity, mortality, and health-care costs
and are difficult to treat and prevent. The majority of asthma exacerbations are associated …

Rationale: Chronic obstructive pulmonary disease (COPD) exacerbations are associated
with virus (mostly rhinovirus) and bacterial infections, but it is not known whether rhinovirus …

In animal models, resident memory CD8+ T (Trm) cells assist in respiratory virus elimination
but their importance in man has not been determined. Here, using experimental human …

BACKGROUND: Asthmatic patients have defective rhinovirus-induced IFN-β and IFN-λ
production from bronchial epithelial cells and IFN-λ from bronchoalveolar lavage (BAL) cells. …