Background The benefits of aerobic training for the main features of asthma, such as bronchial
hyperresponsiveness (BHR) and inflammation, are poorly understood. We investigated …

Upper and lower airways are considered a unified morphological and functional unit, and
the connection existing between them has been observed for many years, both in health and …

Chronic inflammatory airway diseases, including asthma, chronic rhinosinusitis, eosinophilic
COPD and allergic rhinitis are a global health concern. Despite the coexistence of these …

Clinical studies in asthma are not able to clear up all aspects of disease pathophysiology.
Animal models have been developed to better understand these mechanisms and to evaluate …

Background Drugs are responsible for 40% to 60% of anaphylactic reactions treated in the
emergency department. A global research agenda to address uncertainties in anaphylaxis …

OBJECTIVES: Severe asthma is found in approximately 10% of patients with asthma. Some
factors associated with worse asthma control include rhinitis, gastroesophageal reflux …

Background The optimal approach to patients with hypersensitivity reactions (HSRs) to
taxanes has not been established. Objective We sought to assess the safety and efficacy of risk …

BACKGROUND: In recent years, 2 new syndromes of mast cell activation have been
described in patients with episodes of mast cell mediator release that range from flushing and …

Background Rapid drug desensitization (RDD) has become a cornerstone in the management
of immediate drug hypersensitivity reactions (DHRs) to chemotherapeutic agents. …

Perioperative anaphylaxis is a life-threatening condition with an estimated prevalence of 1:3,500
to 1:20,000 procedures and a mortality rate of up to 9 %. Clinical presentation involves …