Incidence of venous thromboembolism in hospitalized patients with COVID‐19

…, J Heijmans, LP Smits, PI Bonta… - … of Thrombosis and …, 2020 - Wiley Online Library
Background Coronavirus disease 2019 (COVID‐19) can lead to systemic coagulation
activation and thrombotic complications. Objectives To investigate the incidence of objectively …

High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages

…, L Mes, M Steenhuis, GR Griffith, PI Bonta… - Science translational …, 2021 - science.org
Patients diagnosed with coronavirus disease 2019 (COVID-19) become critically ill primarily
around the time of activation of the adaptive immune response. Here, we provide evidence …

Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses

PI Bonta, CM Van Tiel, M Vos, TWH Pols… - … , and vascular biology, 2006 - Am Heart Assoc
Objective— Atherosclerosis is an inflammatory disease in which macrophage activation and
lipid loading play a crucial role. In this study, we investigated expression and function of the …

[HTML][HTML] Clinical features and prognostic factors in Covid-19: a prospective cohort study

…, F van Baarle, D Bax, M Beudel, M Bomers, P Bonta… - …, 2021 - thelancet.com
Background Mortality rates are high among hospitalized patients with COVID-19, especially
in those intubated on the ICU. Insight in pathways associated with unfavourable outcome …

Imatinib in patients with severe COVID-19: a randomised, double-blind, placebo-controlled, clinical trial

…, PM Bet, W Boersma, PI Bonta… - The Lancet …, 2021 - thelancet.com
Background The major complication of COVID-19 is hypoxaemic respiratory failure from
capillary leak and alveolar oedema. Experimental and early clinical data suggest that the …

Eosinophils capture viruses, a capacity that is defective in asthma

…, BS Dierdorp, T Dekker, EP Hoefsmit, PI Bonta… - Allergy, 2019 - Wiley Online Library
Background Activated eosinophils cause major pathology in stable and exacerbating asthma;
however, they can also display protective properties like an extracellular antiviral activity. …

Bronchial thermoplasty induced airway smooth muscle reduction and clinical response in severe asthma. The TASMA randomized trial

…, EH Bel, PL Shah, JT Annema, PI Bonta - American journal of …, 2021 - atsjournals.org
Rationale: Bronchial thermoplasty (BT) is a bronchoscopic treatment for severe asthma
targeting airway smooth muscle (ASM). Observational studies have shown ASM mass reduction …

Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia

R Renckens, JJTH Roelofs, PI Bonta, S Florquin… - Blood, 2007 - ashpublications.org
Plasminogen activator inhibitor type-1 (PAI-1) levels are consistently elevated in patients
with severe pneumonia and sepsis and highly predictive for an unfavorable outcome. In …

Anti–IL-5 in mild asthma alters rhinovirus-induced macrophage, B-cell, and neutrophil responses (MATERIAL). A placebo-controlled, double-blind study

…, AH Zwinderman, CJ Majoor, PI Bonta… - American journal of …, 2019 - atsjournals.org
Rationale: Eosinophils drive pathophysiology in stable and exacerbating eosinophilic asthma,
and therefore treatment is focused on the reduction of eosinophil numbers. Mepolizumab, …

[HTML][HTML] Hemodynamic and ventilatory responses during exercise in chronic thromboembolic disease

…, JJ Kloek, R Tepaske, PI Bonta… - The Journal of thoracic …, 2016 - Elsevier
Background Patients with chronic thromboembolic disease (CTED) may suffer from exercise
intolerance without pulmonary hypertension at rest. Pulmonary endarterectomy (PEA) for …