The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory
response in pro-inflammatory "M1" macrophages. However, alternatively activated "M2" …

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer,
ILC2s can harbor both pro-tumorigenic and anti-tumorigenic functions, but we know little …

The microbiota is vital for the development of the immune system and homeostasis. Changes
in microbial composition and function, termed dysbiosis, in the respiratory tract and the gut …

Aberrant T‐cell responses underpin a range of diseases, including asthma and allergy and
autoimmune diseases. Pivotal immune elements of these diseases are the development of …

Microbes or danger signals trigger inflammasome sensors, which induce polymerization of
the adaptor ASC and the assembly of ASC specks. ASC specks recruit and activate caspase-…

Oligonucleotide-based therapies are advanced novel interventions used in the management
of various respiratory diseases such as asthma and Chronic Obstructive Pulmonary …

Background Our view of host-associated microbiota remains incomplete due to the presence
of as yet uncultured constituents. The Bacteroidales family S24-7 is a prominent example of …

Lung diseases are the leading cause of mortality worldwide. The currently available
therapies are not sufficient, leading to the urgent need for new therapies with sustained anti‐…

Listeria monocytogenes is an important food-borne pathogen and is widely tested for in food,
environmental and clinical samples. Identification traditionally involved culture methods …

COPD is a major cause of global mortality and morbidity but current treatments are poorly
effective. This is because the underlying mechanisms that drive the development and …