User profiles for Phuwanat Sakornsakolpat
Phuwanat SakornsakolpatFaculty of Medicine Siriraj Hospital, Mahidol University Verified email at mahidol.edu Cited by 1508 |
Machine learning characterization of COPD subtypes: insights from the COPDGene study
COPD is a heterogeneous syndrome. Many COPD subtypes have been proposed, but there
is not yet consensus on how many COPD subtypes there are and how they should be …
is not yet consensus on how many COPD subtypes there are and how they should be …
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
P Sakornsakolpat, D Prokopenko, M Lamontagne… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis
…, BD Hobbs, RK Putman, P Sakornsakolpat… - American journal of …, 2020 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by
scarring of the lung that is believed to result from an atypical response to injury of the …
scarring of the lung that is believed to result from an atypical response to injury of the …
[HTML][HTML] Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk,
but the individual variants that have been identified have small effects. We hypothesised that …
but the individual variants that have been identified have small effects. We hypothesised that …
[HTML][HTML] Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants
Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a
leading cause of morbidity and mortality. We performed whole genome sequence (WGS) …
leading cause of morbidity and mortality. We performed whole genome sequence (WGS) …
Interaction of cigarette smoking and polygenic risk score on reduced lung function
Importance The risk of airflow limitation and chronic obstructive pulmonary disease (COPD)
is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains …
is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains …
Leveraging lung tissue transcriptome to uncover candidate causal genes in COPD genetic associations
Causal genes of chronic obstructive pulmonary disease (COPD) remain elusive. The current
study aims at integrating genome-wide association studies (GWAS) and lung expression …
study aims at integrating genome-wide association studies (GWAS) and lung expression …
A polygenic risk score for asthma in a large racially diverse population
Background Polygenic risk scores (PRSs) will have important utility for asthma and other
chronic diseases as a tool for predicting disease incidence and subphenotypes. Objective We …
chronic diseases as a tool for predicting disease incidence and subphenotypes. Objective We …
Genome-wide gene-by-smoking interaction study of chronic obstructive pulmonary disease
W Kim, D Prokopenko, P Sakornsakolpat… - American journal of …, 2021 - academic.oup.com
Risk of chronic obstructive pulmonary disease (COPD) is determined by both cigarette
smoking and genetic susceptibility, but little is known about gene-by-smoking interactions. We …
smoking and genetic susceptibility, but little is known about gene-by-smoking interactions. We …