User profiles for Phuwanat Sakornsakolpat

Phuwanat Sakornsakolpat

Faculty of Medicine Siriraj Hospital, Mahidol University
Verified email at mahidol.edu
Cited by 1508

Machine learning characterization of COPD subtypes: insights from the COPDGene study

…, MM Parker, D Prokopenko, D Qiao, P Sakornsakolpat… - Chest, 2020 - Elsevier
COPD is a heterogeneous syndrome. Many COPD subtypes have been proposed, but there
is not yet consensus on how many COPD subtypes there are and how they should be …

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

…, C Batini, KA Fawcett, K Song, P Sakornsakolpat… - Nature …, 2019 - nature.com
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

P Sakornsakolpat, D Prokopenko, M Lamontagne… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …

Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis

…, BD Hobbs, RK Putman, P Sakornsakolpat… - American journal of …, 2020 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by
scarring of the lung that is believed to result from an atypical response to injury of the …

[HTML][HTML] Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts

M Moll, P Sakornsakolpat, N Shrine… - The Lancet …, 2020 - thelancet.com
Background Genetic factors influence chronic obstructive pulmonary disease (COPD) risk,
but the individual variants that have been identified have small effects. We hypothesised that …

[HTML][HTML] Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants

…, T Sofer, SAG Taliun, P Sakornsakolpat… - Nature …, 2020 - nature.com
Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a
leading cause of morbidity and mortality. We performed whole genome sequence (WGS) …

Interaction of cigarette smoking and polygenic risk score on reduced lung function

…, BD Hobbs, N Shrine, P Sakornsakolpat… - JAMA Network …, 2021 - jamanetwork.com
Importance The risk of airflow limitation and chronic obstructive pulmonary disease (COPD)
is influenced by combinations of cigarette smoking and genetic susceptibility, yet it remains …

Leveraging lung tissue transcriptome to uncover candidate causal genes in COPD genetic associations

…, MH Cho, BD Hobbs, P Sakornsakolpat… - Human molecular …, 2018 - academic.oup.com
Causal genes of chronic obstructive pulmonary disease (COPD) remain elusive. The current
study aims at integrating genome-wide association studies (GWAS) and lung expression …

A polygenic risk score for asthma in a large racially diverse population

…, R Kelly, J Lasky‐Su, P Sakornsakolpat… - Clinical & …, 2021 - Wiley Online Library
Background Polygenic risk scores (PRSs) will have important utility for asthma and other
chronic diseases as a tool for predicting disease incidence and subphenotypes. Objective We …

Genome-wide gene-by-smoking interaction study of chronic obstructive pulmonary disease

W Kim, D Prokopenko, P Sakornsakolpat… - American journal of …, 2021 - academic.oup.com
Risk of chronic obstructive pulmonary disease (COPD) is determined by both cigarette
smoking and genetic susceptibility, but little is known about gene-by-smoking interactions. We …