[HTML][HTML] Early high antibody titre convalescent plasma for hospitalised COVID-19 patients: DAWn-plasma

T Devos, Q Van Thillo, V Compernolle… - European respiratory …, 2022 - Eur Respiratory Soc
Background Several randomised clinical trials have studied convalescent plasma for
coronavirus disease 2019 (COVID-19) using different protocols, with different severe acute …

Aberrant MYCN expression drives oncogenic hijacking of EZH2 as a transcriptional activator in peripheral T-cell lymphoma

…, K Debackere, S Demeyer, Q Van Thillo… - Blood, The Journal …, 2022 - ashpublications.org
Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of hematological cancers
arising from the malignant transformation of mature T cells. In a cohort of 28 PTCL cases, we …

[HTML][HTML] Oncogenic cooperation between TCF7-SPI1 and NRAS(G12D) requires β-catenin activity to drive T-cell acute lymphoblastic leukemia

Q Van Thillo, J De Bie, JA Seneviratne… - Nature …, 2021 - nature.com
Spi-1 Proto-Oncogene (SPI1) fusion genes are recurrently found in T-cell acute lymphoblastic
leukemia (T-ALL) cases but are insufficient to drive leukemogenesis. Here we show that …

[HTML][HTML] A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19: the DAWn …

T Vanassche, MM Engelen, Q Van Thillo, J Wauters… - Trials, 2020 - Springer
Background The peak of the global COVID-19 pandemic has not yet been reached, and
many countries face the prospect of a second wave of infections before effective vaccinations …

[HTML][HTML] Azithromycin for treatment of hospitalised COVID-19 patients: a randomised, multicentre, open-label clinical trial (DAWn-AZITHRO)

…, MM Engelen, A Betrains, Q Van Thillo… - ERJ open …, 2022 - Eur Respiratory Soc
Background and objectives Azithromycin was rapidly adopted as a repurposed drug to treat
coronavirus disease 2019 (COVID-19) early in the pandemic. We aimed to evaluate its …

Modulation of thromboinflammation in hospitalized COVID‐19 patients with aprotinin, low molecular weight heparin, and anakinra: The DAWn‐Antico study

MM Engelen, Q Van Thillo, A Betrains… - … and practice in …, 2022 - Wiley Online Library
Background Thromboinflammation plays a central role in severe COVID‐19. The kallikrein
pathway activates both inflammatory pathways and contact‐mediated coagulation. We …

P347: COOPERATION OF TLX3 AND FLT3-ITD IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA IS ENHANCED BY TLE4 INACTIVATION

Q Van Thillo, L Lauwereins, S Demeyer, S Provost… - …, 2022 - journals.lww.com
Background: One fifth of T-cell acute lymphoblastic leukemia (T-ALL) cases is defined by
the aberrant expression of TLX3. Being similar to the closely related TLX1, its expression is …

Oncogenic cooperation in T-cell acute lymphoblastic leukemia: the role of TLX3 and TCF7-SPI1

Q Van Thillo - 2022 - lirias.kuleuven.be
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer, which
arises from the malignant transformation of developing T-cell progenitors. Genetic studies …

[CITATION][C] Revisiting a case of idiopathic hypereosinophilic syndrome with novel molecular techniques identifies a second case of a myeloid/lymphoid neoplasm with …

Q Van Thillo, B Dewaele, J De Bie… - British Journal of …, 2023 - Wiley Online Library
Fusions involving receptor tyrosine kinases (RTKs) play a crucial role in the development of
myeloid/lymphoid neoplasms with eosinophilia (M/LN-eo), 1 a separate disease category in …

3001–ABERRANT MYCN OVEREXPRESSION DRIVES ONCOGENIC HIJACKING OF EZH2 AS A TRANSCRIPTIONAL ACTIVATOR IN PERIPHERAL T CELL …

…, A Veloso, S Demeyer, T Slegers, Q Van Thillo… - Experimental …, 2023 - Elsevier
Peripheral T cell lymphoma (PTCL) is a group of rare but aggressive hematological cancers
arising from the malignant transformation of mature T cells. In a cohort of 28 PTCL cases, we …