User profiles for R. Tal-Singer

Ruth Tal-Singer

TalSi Translational Medicine Consulting, LLC
Verified email at enarespiratory.com
Cited by 27702

Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease

…, J Dickens, I Haq, D Mannino, B Miller, R Tal-Singer… - Thorax, 2013 - thorax.bmj.com
Background Chronic obstructive pulmonary disease (COPD) is a multicomponent condition
that is characterised by airflow obstruction that is not fully reversible and is a major global …

Lessons from ECLIPSE: a review of COPD biomarkers

R Faner, R Tal-Singer, JH Riley, B Celli, J Vestbo… - Thorax, 2014 - thorax.bmj.com
The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE)
study was a large 3-year observational controlled multicentre international study aimed at …

Treatment trials in young patients with chronic obstructive pulmonary disease and pre–chronic obstructive pulmonary disease patients: time to move forward

…, CF Vogelmeier, RA Wise, R Tal-Singer… - American journal of …, 2022 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is the end result of a series of dynamic and
cumulative gene–environment interactions over a lifetime. The evolving understanding of …

[HTML][HTML] Characterisation of COPD heterogeneity in the ECLIPSE cohort

…, BE Miller, S Rennard, EK Silverman, R Tal-Singer… - Respiratory …, 2010 - Springer
Background Chronic obstructive pulmonary disease (COPD) is a complex condition with
pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of …

[HTML][HTML] Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype

…, LD Edwards, SI Rennard, W MacNee, R Tal-Singer… - PloS one, 2012 - journals.plos.org
Background Because chronic obstructive pulmonary disease (COPD) is a heterogeneous
condition, the identification of specific clinical phenotypes is key to developing more effective …

Evaluation of COPD longitudinally to identify predictive surrogate end-points (ECLIPSE)

…, W MacNee, EK Silverman, R Tal-Singer… - European …, 2008 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease and not well
understood. The forced expiratory volume in one second is used for the diagnosis and staging …

[HTML][HTML] Changes in forced expiratory volume in 1 second over time in COPD

…, BE Miller, EK Silverman, R Tal-Singer… - … England Journal of …, 2011 - Mass Medical Soc
Background A key feature of chronic obstructive pulmonary disease (COPD) is an accelerated
rate of decline in forced expiratory volume in 1 second (FEV 1 ), but data on the variability …

Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease

…, N Locantore, J Yates, R Tal-Singer… - American journal of …, 2012 - atsjournals.org
Rationale: Accurate prediction of mortality helps select patients for interventions aimed at
improving outcome. Objectives: Because chronic obstructive pulmonary disease is …

Variants in FAM13A are associated with chronic obstructive pulmonary disease

…, JD Crapo, X Kong, WH Anderson, R Tal-Singer… - Nature …, 2010 - nature.com
We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD)
in three population cohorts, including 2,940 cases and 1,380 controls who were …

[HTML][HTML] Identification and initial characterization of four novel members of the interleukin-1 family

…, DE Griswold, EA Capper, R Tal-Singer… - Journal of Biological …, 2000 - ASBMB
Interleukin-1 (IL-1), fibroblast growth factors (FGFs), and their homologues are secreted
factors that share a common β-barrel structure and act on target cells by binding to cell surface …