User profiles for Rachel C.A. Dancer
Rachel DancerUniversity of Birmingham Verified email at bham.ac.uk Cited by 1352 |
[HTML][HTML] Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)
Rationale Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and
intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory …
intensive therapy unit mortality but has not been assessed as a risk factor for acute respiratory …
[HTML][HTML] Vitamin D attenuates lung injury via stimulating epithelial repair, reducing epithelial cell apoptosis and inhibits TGF-β induced epithelial to mesenchymal …
…, JX Yang, X Hu, M Li, Q Wang, RCA Dancer… - Biochemical …, 2020 - Elsevier
Vitamin D regulates cell proliferation, inhibits cytokines release at sites of inflammation and
reduces inflammatory responses. In this study, the aim was to investigate whether …
reduces inflammatory responses. In this study, the aim was to investigate whether …
Simvastatin improves neutrophil function and clinical outcomes in pneumonia. A pilot randomized controlled clinical trial
Rationale: Population studies suggest improved sepsis outcomes with statins, but the results
of randomized controlled trials in patients with sepsis and organ dysfunction in critical care …
of randomized controlled trials in patients with sepsis and organ dysfunction in critical care …
Pulmonary infections in the elderly lead to impaired neutrophil targeting, which is improved by simvastatin
…, C Sadhra, D Parekh, RCA Dancer… - American journal of …, 2017 - atsjournals.org
Rationale: Dysregulated neutrophil functions with age and sepsis are described. Statins are
associated with improved infection survival in some observational studies, but trials in …
associated with improved infection survival in some observational studies, but trials in …
[HTML][HTML] Vitamin D deficiency in human and murine sepsis
Objectives: Vitamin D deficiency has been implicated as a pathogenic factor in sepsis and
ICU mortality but causality of these associations has not been demonstrated. To determine …
ICU mortality but causality of these associations has not been demonstrated. To determine …
[HTML][HTML] Vitamin D to prevent lung injury following esophagectomy—a randomized, placebo-controlled trial
Objectives: Observational studies suggest an association between vitamin D deficiency and
adverse outcomes of critical illness and identify it as a potential risk factor for the …
adverse outcomes of critical illness and identify it as a potential risk factor for the …
[HTML][HTML] Statin therapy in patients with community-acquired pneumonia
Community-acquired pneumonia (CAP) is the leading cause of death from infection in
developed countries. There is evidence of an association between improved survival from …
developed countries. There is evidence of an association between improved survival from …
[HTML][HTML] Vitamin D to prevent acute lung injury following oesophagectomy (VINDALOO): study protocol for a randomised placebo controlled trial
Background Acute lung injury occurs in approximately 25% to 30% of subjects undergoing
oesophagectomy. Experimental studies suggest that treatment with vitamin D may prevent the …
oesophagectomy. Experimental studies suggest that treatment with vitamin D may prevent the …
[HTML][HTML] Lipoxin A4 promotes lung epithelial repair whilst inhibiting fibroblast proliferation
S Zheng, VK D'Souza, D Bartis, RCA Dancer… - ERJ Open …, 2016 - Eur Respiratory Soc
Therapy that promotes epithelial repair whilst protecting against fibroproliferation is critical
for restoring lung function in acute and chronic respiratory diseases. Primary human alveolar …
for restoring lung function in acute and chronic respiratory diseases. Primary human alveolar …
[HTML][HTML] Simvastatin to modify neutrophil function in older patients with septic pneumonia (SNOOPI): study protocol for a randomised placebo-controlled trial
Background Community-acquired pneumonia (CAP) is considered the leading cause of death
from infectious disease in developed countries, while complications of CAP - sepsis being …
from infectious disease in developed countries, while complications of CAP - sepsis being …