Background Cough is a common and troublesome symptom in asthmatic patients, but little
is known about the neuronal pathways that trigger cough. The mechanisms by which airway …

Objective Baclofen is a centrally acting γ-aminobutyric acid type B (GABA B ) receptor agonist
which reduces gastro-oesophageal reflux and suppresses the cough reflex; however, …

Background Patients with some neuronal hypersensitivity syndromes experience increased
autonomic symptoms. Chronic cough is thought to be a neuronal hypersensitivity disorder …

Background Currently there are no effective licensed anti-tussive therapies. Understanding
how the neuronal mechanisms mediating the cough reflex in animal models translate to …

Chronic cough, as a result of neuronal hypersensitivity, is a disruptive symptom with patients
suffering from impacted quality of life. Cough is vagally mediated, as is the parasympathetic …

Background Preclinical studies suggest that P2X3 receptors are expressed by airway vagal
afferent nerves and contribute to the hypersensitisation of sensory neurons. P2X3 receptors …

Background Inhalation of capsaicin, the extract of hot chili peppers, induces coughing in both
animals and human subjects through activation of transient receptor potential vanilloid 1 (…

… Author links open overlay panel Khaled Al-shair a , Rachel Dockry a , Brendan Mallia-Milanes
a , … Author Rachel Dockry has no financial or other potential conflicts of interest to disclose. …

Background Cough is common in patients with lung cancer, and current antitussive treatments
are suboptimal. There are little published data describing cough in patients with lung …

Rationale: Most airway diseases, including chronic obstructive pulmonary disease (COPD),
are associated with excessive coughing. The extent to which this may be a consequence of …