Stromal contribution to the colorectal cancer transcriptome
…, C Petti, G Galatola, A Muratore, A Mellano, R Senetta… - Nature …, 2015 - nature.com
Recent studies identified a poor-prognosis stem/serrated/mesenchymal (SSM) transcriptional
subtype of colorectal cancer (CRC). We noted that genes upregulated in this subtype are …
subtype of colorectal cancer (CRC). We noted that genes upregulated in this subtype are …
[HTML][HTML] Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer
Stromal content heavily impacts the transcriptional classification of colorectal cancer (CRC),
with clinical and biological implications. Lineage-dependent stromal transcriptional …
with clinical and biological implications. Lineage-dependent stromal transcriptional …
[HTML][HTML] Cancers of unknown primary origin: current perspectives and future therapeutic strategies
GM Stella, R Senetta, A Cassenti, M Ronco… - Journal of translational …, 2012 - Springer
It is widely accepted that systemic neoplastic spread is a late event in tumour progression.
However, sometimes, rapidly invasive cancers are diagnosed because of appearance of …
However, sometimes, rapidly invasive cancers are diagnosed because of appearance of …
[HTML][HTML] NTRK Fusions in Central Nervous System Tumors: A Rare, but Worthy Target
A Gambella, R Senetta, G Collemi, SG Vallero… - International journal of …, 2020 - mdpi.com
The neurotrophic tropomyosin receptor kinase (NTRK) genes (NTRK1, NTRK2, and NTRK3)
code for three transmembrane high-affinity tyrosine-kinase receptors for nerve growth …
code for three transmembrane high-affinity tyrosine-kinase receptors for nerve growth …
Caveolin‐1 as a promoter of tumour spreading: when, how, where and why
R Senetta, G Stella, E Pozzi, N Sturli… - Journal of cellular …, 2013 - Wiley Online Library
Caveolae are non‐clathrin invaginations of the plasma membrane in most cell types; they
are involved in signalling functions and molecule trafficking, thus modulating several …
are involved in signalling functions and molecule trafficking, thus modulating several …
Sentinel Lymph Node Biopsy in Thick-Melanoma Patients (N=350): What is Its Prognostic Role?
…, M Sanlorenzo, E Balagna, R Senetta… - Annals of Surgical …, 2015 - Springer
Background Sentinel lymph node biopsy (SLNB) is currently recommended for patients with
intermediate-thickness melanomas (T2–T3). Historically, T4 melanoma patients have not …
intermediate-thickness melanomas (T2–T3). Historically, T4 melanoma patients have not …
Atypical Spitz tumors in patients younger than 18 years
D Massi, C Tomasini, R Senetta, M Paglierani… - Journal of the American …, 2015 - Elsevier
Background Diagnosis and proper management of atypical Spitz tumors in pediatric age are
still controversial. Objective We sought to investigate the clinicopathological and molecular …
still controversial. Objective We sought to investigate the clinicopathological and molecular …
Favourable prognostic role of regression of primary melanoma in AJCC stage I–II patients
…, G Cavaliere, C Tomasini, R Senetta… - British Journal of …, 2013 - academic.oup.com
Background The prognostic significance of regression in primary melanoma has been debated
over the past few years. Once it was considered to be a negative prognostic factor, as it …
over the past few years. Once it was considered to be a negative prognostic factor, as it …
[HTML][HTML] Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition
…, L Casorzo, S Benvenuti, E Cascardi, R Senetta… - Nature …, 2021 - nature.com
Cancers of unknown primary (CUPs), featuring metastatic dissemination in the absence of a
primary tumor, are a biological enigma and a fatal disease. We propose that CUPs are a …
primary tumor, are a biological enigma and a fatal disease. We propose that CUPs are a …
[HTML][HTML] Prognostic and predictive biomarkers in stage III melanoma: Current insights and clinical implications
…, A Agostini, P Fava, L Bertero, R Senetta… - International journal of …, 2021 - mdpi.com
Melanoma is one of the most aggressive skin cancers. The 5-year survival rate of stage III
melanoma patients ranges from 93% (IIIA) to 32% (IIID) with a high risk of recurrence after …
melanoma patients ranges from 93% (IIIA) to 32% (IIID) with a high risk of recurrence after …