Background The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a
member of the CRISPR (Clustered regularly interspaced short palindromic repeats) …

Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth
and nineteenth centuries and remains a cause of high mortality in developing countries. In …

This paper describes an action framework for countries with low tuberculosis (TB) incidence
(<100 TB cases per million population) that are striving for TB elimination. The framework …

Background Diagnosing drug-resistance remains an obstacle to the elimination of tuberculosis.
Phenotypic drug-susceptibility testing is slow and expensive, and commercial genotypic …

The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug
resistance in clinical samples, and improvements in global surveillance. Here we show how …

Background Understanding Mycobacterium tuberculosis (Mtb) transmission is essential to
guide efficient tuberculosis control strategies. Traditional strain typing lacks sufficient …

Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are
associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here …

Test accuracy of interferon-γ release assays (IGRAs) for diagnosing TB differs when using
older or precommercial tools and inconsistent diagnostic criteria. This metaanalysis critically …

Rationale: Numerous studies have been published on the new Mycobacterium tuberculosis
(MTB)–specific IFN-γ release assays. However, their prognostic value for progression from …

Rationale: Only limited data are available on the predictive value of interferon-γ release
assays for progression from latent tuberculosis infection to active tuberculosis (TB). Objectives: …