Graves' orbitopathy (GO) is a complication in Graves' disease (GD) but mechanistic insights
into pathogenesis remain unresolved, hampered by lack of animal model. The TSH receptor (…

Background Variation in induced models of autoimmunity has been attributed to the housing
environment and its effect on the gut microbiota. In Graves’ disease (GD), autoantibodies to …

Background Graves’ disease (GD) is an autoimmune condition in which autoantibodies to
the thyrotropin receptor (TSHR) cause hyperthyroidism. About 50% of GD patients also have …

BACKGROUND Chronic lung allograft dysfunction (CLAD) is a heterogeneous condition.
Characterization of CLAD phenotypes is essential to enhance the understanding of …

We recently described a preclinical model of Graves' orbitopathy (GO), induced by genetic
immunization of eukaryotic expression plasmid encoding human TSH receptor (TSHR) A-…

Experimental models of hyperthyroid Graves’ disease (GD) and Graves’ orbitopathy (GO)
are efficiently developed by genetic immunisation by electroporation with human thyrotropin …

Background Transmission of latent human cytomegalovirus (HCMV) via organ transplantation
with post-transplant viral reactivation is extremely prevalent and results in substantial …

Background Antibody-mediated rejection (AMR) accounts for> 50% of kidney allograft loss.
Donor-specific antibodies (DSA) against HLA and non-HLA antigens in the glomeruli and the …

BACKGROUND Gastroesophageal reflux disease (GERD) is a risk factor for chronic lung
allograft dysfunction. Bile acids—putative markers of gastric microaspiration—and …

Replacement of diseased organs with transplanted healthy donor ones remains the best
and often only treatment option for end-stage organ disease. Immunosuppressants have …