User profiles for Sajad Moshkelgosha
Sajad MoshkelgoshaUniversity Health Network Verified email at uhn.ca Cited by 648 |
Cutting edge: retrobulbar inflammation, adipogenesis, and acute orbital congestion in a preclinical female mouse model of Graves' orbitopathy induced by thyrotropin …
Graves' orbitopathy (GO) is a complication in Graves' disease (GD) but mechanistic insights
into pathogenesis remain unresolved, hampered by lack of animal model. The TSH receptor (…
into pathogenesis remain unresolved, hampered by lack of animal model. The TSH receptor (…
[HTML][HTML] Gut microbiota in experimental murine model of Graves' orbitopathy established in different environments may modulate clinical presentation of disease
G Masetti, S Moshkelgosha, HL Köhling, D Covelli… - Microbiome, 2018 - Springer
Background Variation in induced models of autoimmunity has been attributed to the housing
environment and its effect on the gut microbiota. In Graves’ disease (GD), autoantibodies to …
environment and its effect on the gut microbiota. In Graves’ disease (GD), autoantibodies to …
[HTML][HTML] Modulating gut microbiota in a mouse model of Graves' orbitopathy and its impact on induced disease
S Moshkelgosha, HL Verhasselt, G Masetti, D Covelli… - Microbiome, 2021 - Springer
Background Graves’ disease (GD) is an autoimmune condition in which autoantibodies to
the thyrotropin receptor (TSHR) cause hyperthyroidism. About 50% of GD patients also have …
the thyrotropin receptor (TSHR) cause hyperthyroidism. About 50% of GD patients also have …
Risk assessment of chronic lung allograft dysfunction phenotypes: validation and proposed refinement of the 2019 International Society for Heart and Lung …
…, E Fuchs, R Ghany, S Moshkelgosha… - The Journal of Heart and …, 2020 - Elsevier
BACKGROUND Chronic lung allograft dysfunction (CLAD) is a heterogeneous condition.
Characterization of CLAD phenotypes is essential to enhance the understanding of …
Characterization of CLAD phenotypes is essential to enhance the understanding of …
Comparative assessment of female mouse model of Graves' orbitopathy under different environments, accompanied by proinflammatory cytokine and T-cell responses …
U Berchner-Pfannschmidt, S Moshkelgosha… - …, 2016 - academic.oup.com
We recently described a preclinical model of Graves' orbitopathy (GO), induced by genetic
immunization of eukaryotic expression plasmid encoding human TSH receptor (TSHR) A-…
immunization of eukaryotic expression plasmid encoding human TSH receptor (TSHR) A-…
Gut microbiome in BALB/c and C57BL/6J mice undergoing experimental thyroid autoimmunity associate with differences in immunological responses and thyroid …
S Moshkelgosha, G Masetti… - Hormone and …, 2018 - thieme-connect.com
Experimental models of hyperthyroid Graves’ disease (GD) and Graves’ orbitopathy (GO)
are efficiently developed by genetic immunisation by electroporation with human thyrotropin …
are efficiently developed by genetic immunisation by electroporation with human thyrotropin …
Ex vivo treatment of cytomegalovirus in human donor lungs using a novel chemokine-based immunotoxin
…, A Ali, M Galasso, S Moshkelgosha… - The Journal of Heart and …, 2022 - Elsevier
Background Transmission of latent human cytomegalovirus (HCMV) via organ transplantation
with post-transplant viral reactivation is extremely prevalent and results in substantial …
with post-transplant viral reactivation is extremely prevalent and results in substantial …
Extracellular matrix injury of kidney allografts in antibody-mediated rejection: a proteomics study
…, SJ Kim, E Chan, S Moshkelgosha… - Journal of the …, 2020 - journals.lww.com
Background Antibody-mediated rejection (AMR) accounts for> 50% of kidney allograft loss.
Donor-specific antibodies (DSA) against HLA and non-HLA antigens in the glomeruli and the …
Donor-specific antibodies (DSA) against HLA and non-HLA antigens in the glomeruli and the …
Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration
…, SE Hunter, KM Boonstra, S Moshkelgosha… - The Journal of Heart and …, 2020 - Elsevier
BACKGROUND Gastroesophageal reflux disease (GERD) is a risk factor for chronic lung
allograft dysfunction. Bile acids—putative markers of gastric microaspiration—and …
allograft dysfunction. Bile acids—putative markers of gastric microaspiration—and …
[HTML][HTML] Intragraft regulatory T cells in the modern era: what can high-dimensional methods tell us about pathways to allograft acceptance?
KF Bei, S Moshkelgosha, BJ Liu, S Juvet - Frontiers in Immunology, 2023 - frontiersin.org
Replacement of diseased organs with transplanted healthy donor ones remains the best
and often only treatment option for end-stage organ disease. Immunosuppressants have …
and often only treatment option for end-stage organ disease. Immunosuppressants have …