BACKGROUND: Increased airway smooth muscle (ASM) is a feature of established asthma
in schoolchildren, but nothing is known about ASM in preschool wheezers. OBJECTIVE: We …

Rationale: Lung clearance index (LCI) is a more sensitive measure of lung function than
spirometry in cystic fibrosis (CF) and correlates well with abnormalities in high-resolution …

Lung function testing in pre-school children in the clinical setting is challenging. Most cannot
perform spirometry and many infant lung function tests require sedation. Lung clearance …

Lung clearance index (LCI) is a potential clinical outcome marker in bronchiectasis. Its
responsiveness to therapeutic intervention has not been determined. This study evaluates its …

Multiple-breath washout (MBW) can be performed with different gases (sulfur hexafluoride (SF
6 ) and nitrogen (N 2 )) and different devices, all of which give discrepant results. This …

Background: Lung clearance index (LCI) is becoming recognized as an important addition
in the monitoring of pediatric cystic fibrosis (CF). The non-invasive technique is easy to …

Children with severe asthma may be treated with biologic agents normally requiring 2–4
weekly injections in hospital. In March 2020, due to COVID-19, we needed to minimise hospital …

Introduction Lung clearance index (LCI) is a measure of airway disease that has been shown
to be abnormal in asthma. We hypothesized that LCI would be higher (worse) in children …

Primary ciliary dyskinesia is a condition in which abnormal cilia structure or function leads to
reduced mucociliary clearance and obstructive lung disease. Twenty-nine patients had lung …

Lung clearance index (LCI) derived from multiple breath washout (MBW) is a sensitive,
noninvasive measure of ventilation heterogeneity and is used for the assessment of cystic fibrosis …