Stop codon readthrough may be promoted by the nucleotide environment or drugs. In such
cases, ribosomes incorporate a natural suppressor tRNA at the stop codon, leading to the …

Some codons of the genetic code can be read not only by cognate, but also by near-cognate
tRNAs. This flexibility is thought to be conferred mainly by a mismatch between the third …

Premature termination codons (PTCs) are generally associated with severe forms of genetic
diseases. Readthrough of in-frame PTCs using small molecules is a promising therapeutic …

In eukaryotes, translation termination is performed by eRF1, which recognizes stop codons
via its N-terminal domain. Many previous studies based on point mutagenesis, cross-linking …

In addition to the conserved translation elongation factors eEF1A and eEF2, fungi require a
third essential elongation factor, eEF3. While eEF3 has been implicated in tRNA binding and …

Protein synthesis in eukaryotes is carried out by 80S ribosomes with the help of many
specific translation factors. Translation comprises four major steps: initiation, elongation, …

This paper reports the synthesis of borosilicate bioactive glasses nanoparticles containing
ions of interest (calcium, strontium or silver ions) for the purpose of bone tissue regeneration …

Pervasive translation is a widespread phenomenon that plays an important role in de novo
gene birth; however, its underlying mechanisms remain unclear. Based on multiple …

In addition to the conserved translation elongation factors eEF1A and eEF2, fungi require a
third essential elongation factor, eEF3. While eEF3 has been implicated in tRNA binding and …

Protein synthesis is an essential and highly regulated cellular process. To facilitate the
understanding of eukaryotic translation, we have assembled an in vitro translation system from …