G3BP1 promotes DNA binding and activation of cGAS

…, JQ Xing, M Zhao, YJ Huang, S Chen, SM Wu… - Nature …, 2019 - nature.com
Cyclic GMP-AMP synthase (cGAS) is a key sensor responsible for cytosolic DNA detection.
Here we report that GTPase-activating protein SH3 domain–binding protein 1 (G3BP1) is …

[HTML][HTML] The role of EREG/EGFR pathway in tumor progression

…, WL Sun, N Van Hiep, CS Luo, SM Wu - International journal of …, 2021 - mdpi.com
Aberrant activation of the epidermal growth factor receptor (EGFR/ERBB1) by erythroblastic
leukemia viral oncogene homolog (ERBB) ligands contributes to various tumor malignancies…

Chromosome 19 open reading frame 80 is upregulated by thyroid hormone and modulates autophagy and lipid metabolism

YH Tseng, PY Ke, CJ Liao, SM Wu, HC Chi, CY Tsai… - Autophagy, 2014 - Taylor & Francis
The thyroid hormone, T 3 , regulates cell growth, differentiation and development through
binding to the nuclear thyroid hormone receptor (THR), a member of the steroid/TR superfamily …

Dickkopf 4 positively regulated by the thyroid hormone receptor suppresses cell invasion in human hepatoma cells

CH Liao, CT Yeh, YH Huang, SM Wu, HC Chi… - …, 2012 - Wiley Online Library
Thyroid hormone (T 3 ) mediates cellular growth, development, and differentiation by
binding to the nuclear thyroid hormone receptor (TR). Recent studies suggest that long‐term …

Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy

…, CY Tsai, WY Chuang, YH Huang, MM Tsai, SM Wu… - Autophagy, 2016 - Taylor & Francis
Recent studies have demonstrated a critical association between disruption of cellular
thyroid hormone (TH) signaling and the incidence of hepatocellular carcinoma (HCC), but the …

Thyroid hormone regulation of miR-21 enhances migration and invasion of hepatoma

YH Huang, YH Lin, HC Chi, CH Liao, CJ Liao, SM Wu… - Cancer research, 2013 - AACR
Thyroid hormone (T 3 ) signaling through the thyroid hormone receptor (TRα1) regulates
hepatoma cell growth and pathophysiology, but the underlying mechanisms are unclear at …

Elevation of CD109 promotes metastasis and drug resistance in lung cancer via activation of EGFR‐AKT‐mTOR signaling

…, BX Lin, MH Lin, DY Kuo, IL Tsai, SM Wu… - Cancer …, 2020 - Wiley Online Library
Lung cancer is the most commonly diagnosed cancer worldwide, and metastasis in lung
cancer is the leading cause of cancer‐related deaths. Thus, understanding the mechanism of …

Repression of microRNA-130b by thyroid hormone enhances cell motility

…, MH Wu, CJ Liao, YH Huang, HC Chi, SM Wu… - Journal of …, 2015 - Elsevier
Background & Aims Thyroid hormone (T 3 ) and its receptor (TR) are involved in cell growth
and cancer progression. Although deregulation of microRNA (miRNA) expression has been …

[HTML][HTML] Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion

…, HC Chi, PJ Tai, CJ Liao, SM Wu… - Endocrine-related …, 2010 - erc.bioscientifica.com
The thyroid hormone 3, 3′, 5-triiodo-l-thyronine (T 3) regulates growth, development, and
differentiation processes in animals. These activities are mediated by the nuclear thyroid …

Lnc-IL7R alleviates PM2.5-mediated cellular senescence and apoptosis through EZH2 recruitment in chronic obstructive pulmonary disease

…, HC Chuang, CH Tseng, TT Chen, SM Wu - Cell Biology and …, 2022 - Springer
Background Long-term exposure to PM 2.5 (particulate matter with an aerodynamic diameter
of ≤ 2.5 μm) is associated with pulmonary injury and emphysema in patients with chronic …