User profiles for Stefano Volpi

Stefano Volpi

Istituto Giannina Gaslini, Universitą degli Studi di Genova, Harvard Medical School
Verified email at gaslini.org
Cited by 6481

On the alert for cytokine storm: immunopathology in COVID‐19

…, SW Canna, GS Schulert, S Volpi… - Arthritis & …, 2020 - Wiley Online Library
Poor outcomes in COVID‐19 correlate with clinical and laboratory features of cytokine storm
syndrome. Broad screening for cytokine storm and early, targeted antiinflammatory therapy …

Bone marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of B cells isolated from healthy donors and systemic lupus …

E Traggiai, S Volpi, F Schena, M Gattorno, F Ferlito… - Stem …, 2008 - academic.oup.com
Human bone marrow multipotent mesenchymal stromal cells are progenitor cells that can be
expanded in vitro and differentiate into various cells of mesodermal origin. They contribute …

[HTML][HTML] A three-dimensional model of human lung development and disease from pluripotent stem cells

…, ALRT De Carvalho, SH Ho, MN Islam, S Volpi… - Nature cell …, 2017 - nature.com
Recapitulation of lung development from human pluripotent stem cells (hPSCs) in three
dimensions (3D) would allow deeper insight into human development, as well as the …

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

…, V Francois-Newton, SD Speer, C Yuan, S Volpi… - Nature, 2015 - nature.com
Intracellular ISG15 is an interferon (IFN)-α/β-inducible ubiquitin-like modifier which can
covalently bind other proteins in a process called ISGylation; it is an effector of IFN-α/β-…

Effect of anakinra on mortality in patients with COVID-19: a systematic review and patient-level meta-analysis

…, EJ Giamarellos-Bourboulis, S Volpi… - The Lancet …, 2021 - thelancet.com
Background Anakinra might improve the prognosis of patients with moderate to severe
COVID-19 (ie, patients requiring oxygen supplementation but not yet receiving organ support). …

Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency

…, SXL Huang, P Luthra, H Garner, Y Itan, S Volpi… - Science, 2015 - science.org
Severe influenza disease strikes otherwise healthy children and remains unexplained. We
report compound heterozygous null mutations in IRF7, which encodes the transcription factor …

[HTML][HTML] Type I interferon-mediated autoinflammation due to DNase II deficiency

…, F Rieux-Laucat, L Seabra, C Uggenti, S Volpi… - Nature …, 2017 - nature.com
Microbial nucleic acid recognition serves as the major stimulus to an antiviral response,
implying a requirement to limit the misrepresentation of self nucleic acids as non-self and the …

Safety and efficacy of early high-dose IV anakinra in severe COVID-19 lung disease

E Pontali, S Volpi, G Antonucci… - Journal of Allergy and …, 2020 - jacionline.org
Stefano Volpi … Henderson LA, Canna SW, Schulert GS, Volpi S, Lee PY, Kernan KF, et al.
On the alert for cytokine storm: immunopathology in COVID-19 [published online ahead of print …

[HTML][HTML] Deficiency in coatomer complex I causes aberrant activation of STING signalling

…, MP Gantier, M Gattorno, M Geyer, S Volpi… - Nature …, 2022 - nature.com
Coatomer complex I (COPI) mediates retrograde vesicular trafficking from Golgi to the
endoplasmic reticulum (ER) and within Golgi compartments. Deficiency in subunit alpha causes …

Overview of STING-associated vasculopathy with onset in infancy (SAVI) among 21 patients

…, C Thumerelle, E Van Aerde, S Volpi… - The Journal of Allergy …, 2021 - Elsevier
Background Gain-of-function mutations in STING1 underlie a type I interferonopathy termed
SAVI (STING-associated vasculopathy with onset in infancy). This severe disease is variably …