[PDF][PDF] SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
…, M Krasnow, M Kuhnemund, R Lafyatis, H Lee, S Leroy… - Cell, 2020 - cell.com
There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS-…
[HTML][HTML] An integrated cell atlas of the lung in health and disease
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …
typically capture only a limited number of donors and disagree on cell type definitions. …
Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised …
…, D Lebeaux, B Lefevre, S Leroy… - The Lancet infectious …, 2022 - thelancet.com
Background The antiviral efficacy of remdesivir against SARS-CoV-2 is still controversial.
We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with …
We aimed to evaluate the clinical efficacy of remdesivir plus standard of care compared with …
[HTML][HTML] Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics
…, L Mamanova, K Manakongtreecheep, S Leroy… - Nature medicine, 2021 - nature.com
Angiotensin-converting enzyme 2 (ACE2) and accessory proteases (TMPRSS2 and CTSL)
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…
are needed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular entry…
[HTML][HTML] The airway microbiota in cystic fibrosis: a complex fungal and bacterial community—implications for therapeutic management
Background Given the polymicrobial nature of pulmonary infections in patients with cystic
fibrosis (CF), it is essential to enhance our knowledge on the composition of the microbial …
fibrosis (CF), it is essential to enhance our knowledge on the composition of the microbial …
Efficacy predictors of lung volume reduction with Zephyr valves in a European cohort
…, M Noppen, A Valipour, S Leroy… - European …, 2012 - Eur Respiratory Soc
The Endobronchial Valve for Emphysema Palliation Trial (VENT) was a multi-centre,
prospective, randomised, controlled trial conducted to evaluate the safety and effectiveness of …
prospective, randomised, controlled trial conducted to evaluate the safety and effectiveness of …
A single-cell atlas of the human healthy airways
Rationale: The respiratory tract constitutes an elaborate line of defense that is based on a
unique cellular ecosystem. Objectives: We aimed to investigate cell population distributions …
unique cellular ecosystem. Objectives: We aimed to investigate cell population distributions …
A multicenter randomized controlled trial of zephyr endobronchial valve treatment in heterogeneous emphysema (TRANSFORM)
…, NH Ten Hacken, H Fallouh, S Leroy… - American journal of …, 2017 - atsjournals.org
Rationale: Single-center randomized controlled trials of the Zephyr endobronchial valve (EBV)
treatment have demonstrated benefit in severe heterogeneous emphysema. This is the …
treatment have demonstrated benefit in severe heterogeneous emphysema. This is the …
Electromagnetic navigation diagnostic bronchoscopy for small peripheral lung lesions
The present study prospectively evaluated the diagnostic yield and safety of electromagnetic
navigation-guided bronchoscopy biopsy, for small peripheral lung lesions in patients where …
navigation-guided bronchoscopy biopsy, for small peripheral lung lesions in patients where …
Lung volume reduction coil treatment vs usual care in patients with severe emphysema: the REVOLENS randomized clinical trial
Importance Therapeutic options for severe emphysema are limited. Lung volume reduction
using nitinol coils is a bronchoscopic intervention inducing regional parenchymal volume …
using nitinol coils is a bronchoscopic intervention inducing regional parenchymal volume …