User profiles for Takanori Asakura

Takanori Asakura

Kitasato University School of Pharmacy
Verified email at kitasato-u.ac.jp
Cited by 4162

[PDF][PDF] SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract

…, K Okuda, CE Edwards, DR Martinez, T Asakura… - Cell, 2020 - cell.com
The mode of acquisition and causes for the variable clinical spectrum of coronavirus disease
2019 (COVID-19) remain unknown. We utilized a reverse genetics system to generate a …

[PDF][PDF] Human lung stem cell-based alveolospheres provide insights into SARS-CoV-2-mediated interferon responses and pneumocyte dysfunction

…, CE Edwards, BE Heaton, A Konkimalla, T Asakura… - Cell stem cell, 2020 - cell.com
Coronavirus infection causes diffuse alveolar damage leading to acute respiratory distress
syndrome. The absence of ex vivo models of human alveolar epithelium is hindering an …

SARS-CoV-2 infection produces chronic pulmonary epithelial and immune cell dysfunction with fibrosis in mice

…, G De la Cruz, MD Evangelista, T Asakura… - Science translational …, 2022 - science.org
A subset of individuals who recover from coronavirus disease 2019 (COVID-19) develop
post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PASC)…

SARS-CoV-2 infection of airway cells causes intense viral and cell shedding, two spreading mechanisms affected by IL-13

…, JA Wykoff, DR Williams, T Asakura… - Proceedings of the …, 2022 - National Acad Sciences
Muco-obstructive lung diseases are typically associated with high risks of COVID-19 severity;
however, allergic asthma showed reduced susceptibility. To investigate viral spread, …

[HTML][HTML] DOCK2 is involved in the host genetics and biology of severe COVID-19

…, S Chubachi, S Okamori, H Terai, A Morita, T Asakura… - Nature, 2022 - nature.com
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge 1
, 2 , 3 , 4 – 5 . Here we conducted a genome-wide association study (GWAS) involving 2,393 …

Secretory cells dominate airway CFTR expression and function in human airway superficial epithelia

…, S Nakano, G Chen, T Kato, T Asakura… - American journal of …, 2021 - atsjournals.org
Rationale: Identification of the specific cell types expressing CFTR (cystic fibrosis [CF]
transmembrane conductance regulator) is required for precision medicine therapies for CF. …

[PDF][PDF] An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2

KC Barnett, Y Xie, T Asakura, D Song, K Liang… - Cell Host & Microbe, 2023 - cell.com
Elevated levels of cytokines IL-1β and IL-6 are associated with severe COVID-19. Investigating
the underlying mechanisms, we find that while primary human airway epithelia (HAE) …

Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration

…, BR Grubb, TD Rogers, H Dang, T Asakura… - Science translational …, 2023 - science.org
Unlike solid organs, human airway epithelia derive their oxygen from inspired air rather
than the vasculature. Many pulmonary diseases are associated with intraluminal airway …

[HTML][HTML] Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force

H Lee, S Chubachi, H Namkoong, T Asakura… - BMC infectious …, 2022 - Springer
Background We aimed to elucidate differences in the characteristics of patients with coronavirus
disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from …

Prevalence and mechanisms of mucus accumulation in COVID-19 lung disease

T Kato, T Asakura, CE Edwards, H Dang… - American journal of …, 2022 - atsjournals.org
Rationale: The incidence and sites of mucus accumulation and molecular regulation of
mucin gene expression in coronavirus (COVID-19) lung disease have not been reported. …