The far upstream element (FUSE) of the human c-myc proto-oncogene stimulates expression
in undifferentiated cells. A FUSE-binding protein (FBP) is present in undifferentiated but not …

Aneuploidy is the hallmark of many human cancers. Recent work has strongly suggested
that chromosome missegregation during mitosis is the main cause of aneuploidy and …

Glucose metabolism is remodeled in cancer, but the global pattern of cancer-specific
metabolic changes remains unclear. Here we show, using the comprehensive measurement of …

Cohesin complex acts in the formation and maintenance of sister chromatid cohesion
during and after S phase. Budding yeast Scc1p/Mcd1p, an essential subunit, is cleaved and …

The condensin complex in frog extracts, containing two SMC (structural maintenance
ofchromosomes) and three non-SMC subunits, promotes mitotic chromosome condensation, and …

A homopurine/homopyrimidine-like sequence is found 100-150 base pairs upstream of the
human c-myc promoter P1. This element, termed the CT-element, has been shown to …

Sequence specific regulators of eukaryotic gene expression, axiomatically, act through double
stranded DNA targets. Proteins that recognize DNA cis-elements as single strands but for …

The centromere is a chromatin structure essential for correct segregation of sister chromatids,
and defects in this region often lead to aneuploidy and cancer. We have previously …

The CT element of the c- myc gene is required for promoter P1 usage and can drive expression
of a heterologous promoter. Both double strand (Sp1) and single strand (hnRNP K) CT-…

Head and neck squamous cell carcinoma (HNSCC) is usually found at a late stage and
distant metastasis occurs at high frequency; therefore, novel prognostic markers are needed. …