True-atomic-resolution insights into the structure and functional role of linear chains and low-barrier hydrogen bonds in proteins

V Borshchevskiy, K Kovalev, E Round… - Nature Structural & …, 2022 - nature.com
Hydrogen bonds are fundamental to the structure and function of biological macromolecules
and have been explored in detail. The chains of hydrogen bonds (CHBs) and low-barrier …

Structural insights into ion conduction by channelrhodopsin 2

O Volkov, K Kovalev, V Polovinkin, V Borshchevskiy… - Science, 2017 - science.org
INTRODUCTION Ion channels are integral membrane proteins that upon stimulation modulate
the flow of ions across the cell or organelle membrane. The resulting electrical signals are …

Structure and mechanisms of sodium-pumping KR2 rhodopsin

…, A Alekseev, V Shevchenko, V Borshchevskiy… - Science …, 2019 - science.org
Rhodopsins are the most universal biological light-energy transducers and abundant
phototrophic mechanisms that evolved on Earth and have a remarkable diversity and potential for …

[HTML][HTML] Molecular mechanism of light-driven sodium pumping

…, X Carpena, R Boer, N Maliar, V Borshchevskiy… - Nature …, 2020 - nature.com
The light-driven sodium-pumping rhodopsin KR2 from Krokinobacter eikastus is the only
non-proton cation active transporter with demonstrated potential for optogenetics. However, the …

Crystal structure of a light-driven sodium pump

…, A Alekseev, E Round, V Borshchevskiy… - Nature structural & …, 2015 - nature.com
Recently, the first known light-driven sodium pumps, from the microbial rhodopsin family,
were discovered. We have solved the structure of one of them, Krokinobacter eikastus …

Mechanism of transmembrane signaling by sensor histidine kinases

…, S Grudinin, E Round, T Balandin, V Borshchevskiy… - Science, 2017 - science.org
INTRODUCTION Microorganisms obtain most of the information about their environments
through membrane-associated signaling systems. One of the most abundant classes of …

Inward H+ pump xenorhodopsin: Mechanism and alternative optogenetic approach

…, R Ghai, I Gushchin, V Borshchevskiy… - Science …, 2017 - science.org
Generation of an electrochemical proton gradient is the first step of cell bioenergetics. In
prokaryotes, the gradient is created by outward membrane protein proton pumps. Inward …

Structural insights into the proton pumping by unusual proteorhodopsin from nonmarine bacteria

…, E Round, V Borshchevskiy… - Proceedings of the …, 2013 - National Acad Sciences
Light-driven proton pumps are present in many organisms. Here, we present a high-resolution
structure of a proteorhodopsin from a permafrost bacterium, Exiguobacterium sibiricum …

High-resolution structural insights into the heliorhodopsin family

…, T Balandin, V Borshchevskiy… - Proceedings of the …, 2020 - National Acad Sciences
Rhodopsins are the most abundant light-harvesting proteins. A new family of rhodopsins,
heliorhodopsins (HeRs), has recently been discovered. Unlike in the known rhodopsins, in …

[HTML][HTML] Unique structure and function of viral rhodopsins

…, R Rosselli, C Baeken, V Borshchevskiy… - Nature …, 2019 - nature.com
Recently, two groups of rhodopsin genes were identified in large double-stranded DNA
viruses. The structure and function of viral rhodopsins are unknown. We present functional …