[HTML][HTML] IQOS exposure impairs human airway cell homeostasis: direct comparison with traditional cigarette and e-cigarette

SS Sohal, MS Eapen, VGM Naidu… - ERJ open research, 2019 - Eur Respiratory Soc
Heat-not-burn (HNB) devices can alter vital physiological functions in the lung. HNB devices
may not be a safer option than cigarette smoking or eCig vaping; this does not support the …

Arachidonic acid and lipoxinA4 attenuate streptozotocin-induced cytotoxicity to RIN5 F cells in vitro and type 1 and type 2 diabetes mellitus in vivo

NKV Gundala, VGM Naidu, UN Das - Nutrition, 2017 - Elsevier
Objective The aim of this study was to observe whether polyunsaturated fatty acids (PUFAs)
can protect rat insulinoma (RIN5 F) cells against streptozotocin (STZ)-induced apoptosis in …

Arachidonic acid and lipoxin A4 attenuate alloxan‐induced cytotoxicity to RIN5F cells in vitro and type 1 diabetes mellitus in vivo

NKV Gundala, VGM Naidu, UN Das - BioFactors, 2017 - Wiley Online Library
Objective: We studied whether polyunsaturated fatty acids (PUFAs) can protect rat insulinoma
(RIN5F) cells against alloxan‐induced apoptosis in vitro and type 1 diabetes mellitus (type …

Amelioration of streptozotocin-induced type 2 diabetes mellitus in Wistar rats by arachidonic acid

NKV Gundala, VGM Naidu, UN Das - Biochemical and Biophysical …, 2018 - Elsevier
Traditionally arachidonic acid (AA, 20:4 n-6) is considered as a pro-inflammatory molecule
since it forms precursor to prostaglandins (PGs), leukotrienes (LTs) and thromboxanes (TXs) …

Photo-electro active nanocomposite silk hydrogel for spatiotemporal controlled release of chemotherapeutics: an in vivo approach toward suppressing solid tumor …

…, B Gawali, PK Jadi, VGM Naidu… - … applied materials & …, 2020 - ACS Publications
Conventional systemic chemotherapeutic regimens suffer from challenges such as nonspecificity,
shorter half-life, clearance of drugs, and dose-limiting toxicity. Localized delivery of …

Pyridine-Based 1, 2, 4-Triazolo-Tethered Indole Conjugates Potentially Affecting TNKS and PI3K in Colorectal Cancer

PA Yakkala, SR Panda, VGM Naidu… - ACS Medicinal …, 2023 - ACS Publications
A library of pyridine-based 1,2,4-triazolo-tethered indole conjugates were designed,
synthesized, and evaluated for anti-proliferative activity against a panel of six human cancer cell …

[HTML][HTML] Design, synthesis, molecular docking, and biological evaluation of pyrazole hybrid chalcone conjugates as potential anticancer agents and tubulin …

…, O Alam, A Perwez, MA Rizvi, MJ Naim, VGM Naidu… - Pharmaceuticals, 2022 - mdpi.com
Some (E)-3-(3-(4-(benzyloxy)phenyl)-1-phenyl-1H-pyrazol-4-yl)-1-phenylprop-2-en-1-one
conjugates 5a–r were designed; synthesized; characterized by 1 H, 13 C NMR, and ESI-MS; …

Enhanced Pharmacokinetics and Anti-inflammatory Activity of Curcumin Using Dry Emulsion as Drug Delivery Vehicle

M Nayakula, MK Jeengar, VGM Naidu… - European Journal of Drug …, 2023 - Springer
Background and Objective Many naturally available dietary molecules such as curcumin
have not seen the market due to poor solubility, bioavailability, and photodegradability. …

IITZ-01, a novel potent lysosomotropic autophagy inhibitor, has single-agent antitumor efficacy in triple-negative breast cancer in vitro and in vivo

…, S Ragampeta, JR Vaidya, R Sistla, NGM Vegi - Oncogene, 2019 - nature.com
Autophagy is a homeostatic process that recycles damaged organelles and long-lived
proteins by delivering them in double-membrane vesicles to lysosomes for degradation. …

Design, synthesis, and anticancer evaluation of new 1, 3, 4-oxadiazole thioether derivatives

…, JS Anireddy, U Brahma, GM Naidu Vegi - Russian Chemical …, 2021 - Springer
A series of new 1,3,4-oxadiazole derivatives bearing the 2-positioned 2,5-dimethoxyphenyl
substituent and 5-positioned organylsulfanyl moiety were designed and synthesized. …