Longitudinal profiling of the lung microbiome in the AERIS study demonstrates repeatability of bacterial and eosinophilic COPD exacerbations
Background Alterations in the composition of the lung microbiome associated with adverse
clinical outcomes, known as dysbiosis, have been implicated with disease severity and …
clinical outcomes, known as dysbiosis, have been implicated with disease severity and …
Impact and associations of eosinophilic inflammation in COPD: analysis of the AERIS cohort
VL Kim, NA Coombs, KJ Staples… - European …, 2017 - Eur Respiratory Soc
Eosinophilic inflammation in chronic obstructive pulmonary disease (COPD) predicts
response to treatment, especially corticosteroids. We studied the nature of eosinophilic …
response to treatment, especially corticosteroids. We studied the nature of eosinophilic …
[HTML][HTML] Drivers of year-to-year variation in exacerbation frequency of COPD: analysis of the AERIS cohort
The association between exacerbation aetiology and exacerbation frequency is poorly
understood. We analysed 2-year follow-up data from a prospective observational study of …
understood. We analysed 2-year follow-up data from a prospective observational study of …
Relationship between pulmonary matrix metalloproteinases and quantitative CT markers of small airways disease and emphysema in COPD
Background Matrix metalloproteinases (MMPs) are proteolytic enzymes that can degrade
the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of …
the extracellular matrix and drive tissue remodelling, key processes in the pathogenesis of …
A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD
Background The aetiology of acute exacerbations of COPD (AECOPD) is incompletely
understood. Understanding the relationship between chronic bacterial airway infection and viral …
understood. Understanding the relationship between chronic bacterial airway infection and viral …
[HTML][HTML] Impact of radiologically stratified exacerbations: insights into pneumonia aetiology in COPD
NP Williams, K Ostridge, JM Devaster, V Kim… - Respiratory …, 2018 - Springer
Background COPD patients have increased risk of developing pneumonia, which is associated
with poor outcomes. It can be symptomatically indistinguishable from exacerbations, …
with poor outcomes. It can be symptomatically indistinguishable from exacerbations, …
[HTML][HTML] Relationship of CT-quantified emphysema, small airways disease and bronchial wall dimensions with physiological, inflammatory and infective measures in …
K Ostridge, NP Williams, V Kim, S Harden, S Bourne… - Respiratory …, 2018 - Springer
Background COPD is a complex, heterogeneous disease characterised by progressive
development of airflow limitation. Spirometry provides little information about key aspects of …
development of airflow limitation. Spirometry provides little information about key aspects of …
[HTML][HTML] Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases
K Ostridge, N Williams, V Kim, S Harden, S Bourne… - Respiratory …, 2016 - Springer
Background Emphysema is characterised by distinct pathological sub-types, but little is
known about the divergent underlying aetiology. Matrix-metalloproteinases (MMPs) are …
known about the divergent underlying aetiology. Matrix-metalloproteinases (MMPs) are …
Abstract CT034: Results from phase 3 KEYLYNK-008: Pembrolizumab (pembro) with and without maintenance olaparib (ola) after first-line (1L) pembro plus …
…, TM Kim, SW Kim, O Ozyilkan, M Smagina, L Viktoriya… - Cancer Research, 2024 - AACR
Introduction: 1L pembro + chemo significantly improved OS vs chemo for metastatic
sqNSCLC in the KEYNOTE-407 study. Poly(ADP-ribose) polymerase inhibitors (PARPi) can …
sqNSCLC in the KEYNOTE-407 study. Poly(ADP-ribose) polymerase inhibitors (PARPi) can …
Tabunka Kyōsei without immigration policy: The role of centers for international exchange and their challenges
V Kim, P Streich - Contemporary Japan, 2020 - Taylor & Francis
Japan today faces several demographic-related challenges: population decline, an aging
population, and a declining workforce. One of the proposed solutions to these challenges is to …
population, and a declining workforce. One of the proposed solutions to these challenges is to …