Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator–activated receptor-γ activation

…, RA Wagner, S Schellong, VA de Jesus Perez… - Circulation, 2007 - Am Heart Assoc
Background— Patients with pulmonary arterial hypertension (PAH) have reduced expression
of apolipoprotein E (apoE) and peroxisome proliferator–activated receptor-γ in lung tissues…

[HTML][HTML] An antiproliferative BMP-2/PPARγ/apoE axis in human and murine SMCs and its role in pulmonary hypertension

G Hansmann, VA de Jesus Perez… - The Journal of …, 2008 - Am Soc Clin Investig
Loss-of-function mutations in bone morphogenetic protein receptor II (BMP-RII) are linked to
pulmonary arterial hypertension (PAH); the ligand for BMP-RII, BMP-2, is a negative …

Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt–β-catenin and Wnt–RhoA–Rac1 pathways

VA de Jesus Perez, TP Alastalo, JC Wu… - The Journal of cell …, 2009 - rupress.org
Mutations in bone morphogenetic protein (BMP) receptor II (BMPRII) are associated with
pulmonary artery endothelial cell (PAEC) apoptosis and the loss of small vessels seen in …

[HTML][HTML] Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: a global perspective

…, G Butrous, NW Morrell, VA de Jesus Perez… - Nature Reviews …, 2022 - nature.com
The lungs are the primary target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection, with severe hypoxia being the cause of death in the most critical cases. …

MiR-133a modulates osteogenic differentiation of vascular smooth muscle cells

…, DA Mao, Q Lu, XM Zhou, VA de Jesus Perez… - …, 2013 - academic.oup.com
Arterial calcification is a key pathologic component of vascular diseases such as
atherosclerosis, coronary artery disease, and peripheral vascular disease. A hallmark of this …

[HTML][HTML] The 6th World Symposium on Pulmonary Hypertension: what's old is new

…, R Anderson, S Mirza, VA de Jesus Perez - …, 2019 - ncbi.nlm.nih.gov
In February 2018, the 6th World Symposium on Pulmonary Hypertension (WSPH) brought
together experts from various disciplines to review the most relevant clinical and scientific …

Loss of endothelium-derived Wnt5a is associated with reduced pericyte recruitment and small vessel loss in pulmonary arterial hypertension

…, U Demirci, W Tian, MR Nicolls, VA de Jesus Perez - Circulation, 2019 - Am Heart Assoc
Background: Pulmonary arterial hypertension (PAH) is a life-threatening disorder of the
pulmonary circulation associated with loss and impaired regeneration of microvessels. Reduced …

Whole-Exome Sequencing Reveals TopBP1 as a Novel Gene in Idiopathic Pulmonary Arterial Hypertension

VA de Jesus Perez, K Yuan… - American journal of …, 2014 - atsjournals.org
Rationale: Idiopathic pulmonary arterial hypertension (IPAH) is a life-threatening disorder
characterized by progressive loss of pulmonary microvessels. Although mutations in the bone …

New and emerging therapies for pulmonary arterial hypertension

…, SM Kawut, VA de Jesus Perez - Annual Review of …, 2019 - annualreviews.org
Pulmonary arterial hypertension (PAH) is a pulmonary vasculopathy that causes right
ventricular dysfunction and exercise limitation and progresses to death. New findings from …

Long noncoding RNA TYKRIL plays a role in pulmonary hypertension via the p53-mediated regulation of PDGFRβ

…, F Khassafi, K Yuan, VA de Jesus Perez… - American Journal of …, 2020 - atsjournals.org
Rationale: Long noncoding RNAs (lncRNAs) are emerging as important regulators of diverse
biological functions. Their role in pulmonary arterial hypertension (PAH) remains to be …